ADC linker

ADC linkers are specialized chemical structures that connect cytotoxic payloads to monoclonal antibodies in antibody-drug conjugates (ADCs). These linkers are designed to maintain high stability in systemic circulation while enabling controlled drug release within target cells. Depending on their design, linkers may respond to intracellular triggers such as enzymatic cleavage, acidic pH, or reductive environments. The linker architecture and conjugation strategy directly influence the homogeneity, stability, and pharmacokinetic properties of ADCs.