Advanced Reaction Tech
Empowering Next-Generation Therapeutics through Innovative Platform Technologies
Platforms
Advanced continuous flow technology enabling millisecond-precision mass and heat transfer through microreactors.
As an advanced continuous flow technology, flow chemistry enables millisecond-precision mass and heat transfer through microreactors, offering breakthrough solutions for the synthesis of highly active pharmaceutical ingredients (APIs) and intermediates. This technology effectively addresses stability challenges of heat/oxygen-sensitive substances, enables precise control of chiral selectivity, significantly improves atom economy and production continuity, while overcoming common industry challenges including degradation, metal contamination, and structural heterogeneity.
Core Capabilities
- Azide and diazo reactions, continuous nitration
- Continuous photochemical reactions
- Oxidation involving air/oxygen or peroxides
- Continuous ozonolysis
- Continuous hydrogenation
- High-temperature and high-pressure reactions
- Low-temperature organometallic reactions
- Continuous ADC drug synthesis
- Continuous biocatalysis using immobilized enzymes
Our chemical engineering laboratory offers end-to-end continuous flow process development capabilities, equipped with microreactors, photochemical reactors, continuous catalytic hydrogenation systems, coil reactors, and auxiliary units. We specialize in customizing efficient, stable, and scalable continuous flow processes for API and intermediate synthesis.
High efficiency, excellent selectivity, and cost advantages for pharmaceutical manufacturing.
Biocatalysis is increasingly becoming a key technology in large-scale pharmaceutical manufacturing due to its high efficiency, excellent selectivity, and cost advantages. CHEMOS has built an integrated, end-to-end CDMO service platform covering enzyme screening, fermentation, process development, and scale-up production support, supported by an experienced biocatalysis team and advanced facilities.
What We Offer
- Enzyme Development: Enzyme gene mining, directed evolution, enzyme library screening
- Process Development & Optimization: Reaction condition screening, parameter optimization, kinetic studies
- Pilot Scale-Up: Process validation, stability studies, scale-up
- Scale-Up Production: quality-managed manufacturing support from hundreds of grams to hundreds of kilograms
Stereoselective molecule construction for chiral intermediates and APIs.
Chiral synthesis technology addresses the critical challenge of substantial API bioactivity loss caused by stereochemical deviations. By integrating core technologies including stereodirected catalysis, enzymatic biotransformation, and microfluidic process control, we enable efficient and precise construction of complex chiral molecules.
Core Capabilities
- Stereodirected Catalysis: Precise construction of chiral centers with high enantioselectivity
- Enzymatic Biotransformation: Highly stereoselective transformations under mild conditions
- Chiral Resolution & Purification: Supporting target configurations and optical-purity control
- Continuous-Flow Chiral Synthesis: Process intensification through integration with microreactor technology
Cryogenic reaction capabilities from -90°C batch to -110°C continuous flow.
Low-temperature synthesis technology addresses the critical challenges of degradation and inactivation of thermosensitive APIs and intermediates during synthesis. Leveraging dual-platform capabilities at -90°C (batch) and -110°C (continuous flow), combined with industrial-scale cryogenic reactors, energy-efficient continuous flow processes, and molecular-level temperature control.
Core Capabilities
- Low-Temperature Grignard Reactions: Effectively avoiding side reactions and improving chiral intermediate purity
- Halogen-Metal Exchange: Highly selective arylation/heteroarylation via lithiation
- Cryogenic Conjugation of Highly Active Molecules: Ensuring coupling efficiency and product stability for ADCs
- Synthesis of Thermosensitive Bioactive Molecules: Maximally preserving structure-activity relationships
- Low-Temperature Organometallic Reactions: Precise transformations involving butyl lithium and LDA
Industrial-scale hydrogenation with 4-9 MPa high-pressure reaction systems.
The high-pressure chemistry platform specializes in industrial-scale hydrogenation for the synthesis of APIs and intermediates. By integrating 4-9 MPa high-pressure reaction systems with intelligent constant-pressure control technology, combined with inherently safe continuous-flow design and microreactor platforms.
Core Capabilities
- Industrial-Scale High-Pressure Hydrogenation: 300-3,000L Hastelloy reactors at 4-9 MPa
- Precise Process Control: Intelligent constant-pressure control with ±0.1 MPa dynamic regulation
- Real-Time Monitoring & Data-Driven Operation: Hydrogen absorption kinetics monitoring
- Inherently Safe Design: Integration with continuous-flow technology for risk-free operation
- Highly Selective Reduction: Olefins, nitro groups, nitriles with precise chiral center construction
Light-driven chemical reactions with continuous-flow photoreactors.
The photochemistry platform utilizes continuous-flow photoreactors with customized full-spectrum LED light sources and millimeter-scale microfluidic channels to achieve millisecond mixing and highly efficient photon utilization, significantly enhancing reaction selectivity and energy efficiency.
What We Offer
- Photo-cyclization/Ring-Opening: Photo-induced cyclization and ring-opening rearrangement reactions
- Photo-redox Reactions: Visible light-driven single electron transfer processes
- Photo-initiated Free Radical Reactions: Radical transformations under mild conditions
- Photo-isomerization: Stereoselective construction of target configurations
- Photo-oxidation: Highly selective oxygen functionalization
Integrated solid-form development services for small-molecule drugs.
Leveraging advanced instrumentation, our platform offers integrated development services for small-molecule drugs, spanning from solid-form screening to industrial-scale manufacturing. We specialize in the systematic development of polymorphs, salts, and co-crystals.
What We Offer
- Solid-form screening (salts, co-crystals, polymorphs, amorphous forms, solvates/hydrates)
- Crystallization process development from gram to kilogram scale
- Chiral resolution via crystallization
- Powder processing (dry/wet milling, integrated crystallization-milling, spray drying)
- Comprehensive characterization (XRPD, TGA, DSC, DVS, HPLC)
- Solid-state stability and dissolution studies
Advanced chromatographic separation solutions from milligram to kilogram scale.
Our platform specializes in providing efficient and precise separation and purification solutions from milligram to kilogram scale for innovative APIs and high-value intermediates. Equipped with multiple advanced chromatographic technologies.
Core Capabilities
- Preparative HPLC (Normal/Reverse Phase): Precise separation of APIs and intermediates
- Supercritical Fluid Chromatography (SFC): Efficient chiral resolution with reduced solvent consumption
- Centrifugal Partition Chromatography (CPC): Solid support-free system for polar compounds
- Purification of Closely Related Analogs: High-resolution separation
- Impurity Isolation & Preparation: Enrichment and structural confirmation
- Peptide Purification: Reversed-phase preparative purification