Integrated CDMO Services
From target review to route development, custom synthesis, and project-specific scale-up planning
CDMO Services
CHEMOS CDMO projects usually begin with a technical review of the target molecule. Our team looks at the proposed structure, route options, key starting materials, impurity risks, analytical requirements, and requested quantity. Based on that review, we help customers choose a practical path for custom synthesis, process optimization, or scale-up preparation.
Target & Route Review
When a customer shares a target structure, our first work is to understand what is known and what still needs to be proven. We review possible routes, starting-material access, sensitive functional groups, salt or ester form, expected impurities, and the amount needed for the next project step. This helps decide whether the request should start as custom synthesis, route scouting, or a broader process-development task.
Route Optimization & Process Development
Once a route is workable, the next question is whether it can be made more predictable. Our team studies reaction conditions, workup, purification, impurity formation, and analytical controls so the process can be discussed in terms of risk, yield, quality, and scale-up feasibility. This is especially useful for ADC linkers, DOTA/NOTA chelators, heterocycles, metal-containing compounds, and other structures where small route choices can affect the whole project.
Custom Synthesis
Custom synthesis is useful when the target compound is unavailable, hard to source, or needs a specific salt, ester, linker, impurity profile, or quantity. CHEMOS reviews the structure and requested specification, then proposes a route, sample-preparation plan, and analytical approach. Typical work includes LNP and GalNAc-related components, ADC linkers, DOTA/NOTA chelators, PROTAC-related intermediates, molecular glues, heterocycles, sulfur or selenium compounds, phosphorus compounds, metal complexes, and other specialty organic molecules.
Project-Specific Scale-Up Support
Scale-up is handled as a technical decision, not just a larger batch size. Before moving forward, CHEMOS reviews the route, heat and mixing behavior, impurity controls, purification method, requested specification, documentation needs, and supply schedule. Our production base can support suitable projects from pilot preparation toward larger project-specific quantities.
Analytical Method & Quality Review
Good project decisions depend on data that can be read and discussed clearly. Our analytical team supports method development, impurity characterization, structural confirmation, stability-related studies when needed, and batch-specific data review. HPLC, LC-MS, NMR, GC, and related tools are used according to the molecule and project stage.
Services
CDMO Services
CHEMOS CDMO projects usually begin with a technical review of the target molecule. Our team looks at the proposed structure, route options, key starting materials, impurity risks, analytical requirements, and requested quantity. Based on that review, we help customers choose a practical path for custom synthesis, process optimization, or scale-up preparation.
Target & Route Review
Clarifying the molecule, route options, and first technical risks
When a customer shares a target structure, our first work is to understand what is known and what still needs to be proven. We review possible routes, starting-material access, sensitive functional groups, salt or ester form, expected impurities, and the amount needed for the next project step. This helps decide whether the request should start as custom synthesis, route scouting, or a broader process-development task.
Key Capabilities
- Synthetic Route Design - Design and screen efficient synthetic pathways using extensive building block resources and advanced synthetic chemistry expertise.
- Custom Building Block Synthesis - Prepare molecular fragments and key intermediates to support complex molecule construction.
- Early Process Feasibility Assessment - Evaluate scalability, safety, and cost-effectiveness of synthetic routes at the early stage.
- Research Sample Preparation - Deliver milligram- to gram-scale compounds for research evaluation and early project studies.
Core Strengths
- Expertise in challenging chemistries (fluorination, boron chemistry, hydrogenation)
- Advanced platforms such as flow chemistry and biocatalysis
- Experience across multiple therapeutic targets
Route Optimization & Process Development
Turning a workable synthesis into a more controlled process
Once a route is workable, the next question is whether it can be made more predictable. Our team studies reaction conditions, workup, purification, impurity formation, and analytical controls so the process can be discussed in terms of risk, yield, quality, and scale-up feasibility. This is especially useful for ADC linkers, DOTA/NOTA chelators, heterocycles, metal-containing compounds, and other structures where small route choices can affect the whole project.
Service Scope
- Process Optimization - Develop efficient, IP-friendly, and cost-competitive synthetic routes.
- Process Characterization - Use Design of Experiments (DoE) to define critical process parameters and establish robust operating ranges.
- Safety Evaluation - Conduct thermal risk analysis and calorimetric studies to ensure safe scale-up.
- Impurity Profiling - Identify and control process-related impurities, including genotoxic impurities.
- Technology Transfer - Enable smooth transfer of optimized processes to pilot or manufacturing facilities.
Value to Clients
- Reduced development risks
- Improved manufacturing efficiency
- Faster progression to project-specific supply planning
Custom Synthesis
Preparing the target material when catalog supply is not enough
Custom synthesis is useful when the target compound is unavailable, hard to source, or needs a specific salt, ester, linker, impurity profile, or quantity. CHEMOS reviews the structure and requested specification, then proposes a route, sample-preparation plan, and analytical approach. Typical work includes LNP and GalNAc-related components, ADC linkers, DOTA/NOTA chelators, PROTAC-related intermediates, molecular glues, heterocycles, sulfur or selenium compounds, phosphorus compounds, metal complexes, and other specialty organic molecules.
Service Workflow
- Project Assessment - Clarify target structure, target specification, quantity, and requested project timing.
- Route Design - Develop customized synthetic pathways based on molecular complexity.
- Lab-Scale Synthesis - Rapid laboratory synthesis and optimization to generate initial samples.
- Scale-Up Support - Prepare project-specific quantities through suitable laboratory or pilot equipment.
- Purification & Delivery - Apply crystallization, chromatography, or distillation to ensure product quality.
Reaction Expertise
- Friedel-Crafts Reactions, Halogenation Reactions, Grignard Reactions
- Coupling Reactions (e.g., Suzuki, Heck, Sonogashira)
- Chiral Asymmetric Synthesis (e.g., Asymmetric Reduction, Alkylation)
- Heterocyclic Compound Synthesis
Project-Specific Scale-Up Support
Scale-up is handled as a technical decision, not just a larger batch size. Before moving forward, CHEMOS reviews the route, heat and mixing behavior, impurity controls, purification method, requested specification, documentation needs, and supply schedule. Our production base can support suitable projects from pilot preparation toward larger project-specific quantities.
Production Capabilities
- Quality-Managed Production - Operate multi-purpose production facilities under documented quality systems and project-specific requirements.
- Scale-Up Support - Support preparation from kilogram scale to larger project-specific quantities.
- Quality Assurance - Implement strict quality control covering raw materials, intermediates, and final products.
- Process Review - Support process review, analytical confirmation, and documentation preparation according to project needs.
- Lifecycle Management - Continuous improvement and cost optimization for mature projects.
Key Advantages
- Practical scale-up and production-base support
- Documented quality and analytical review
- Flexible capacity planning and supply coordination
Analytical Method & Quality Review
Making the chemistry easier to verify and discuss
Good project decisions depend on data that can be read and discussed clearly. Our analytical team supports method development, impurity characterization, structural confirmation, stability-related studies when needed, and batch-specific data review. HPLC, LC-MS, NMR, GC, and related tools are used according to the molecule and project stage.
Analytical Services
- Method Development - Develop analytical methods for raw materials, intermediates, and APIs.
- Method Validation - Validate analytical methods in accordance with applicable ICH guidance and project quality requirements.
- Impurity Identification - Characterize and quantify impurities using advanced analytical technologies.
- Stability Studies - Conduct stability testing to support product understanding and documentation.
- Quality Documentation - Provide analytical data packages for customer technical review and documentation needs.
Analytical Technologies
- HPLC / UPLC
- GC / GC-MS
- LC-MS / HRMS
- NMR spectroscopy
- Solid-state characterization
