PROTAC

PROTACs (Proteolysis Targeting Chimeras) are heterobifunctional molecules designed to induce selective degradation of disease-related proteins. A typical PROTAC consists of a ligand for the target protein, a ligand for an E3 ubiquitin ligase, and a linker connecting the two. By bringing the target protein into proximity with the E3 ligase, PROTAC molecules promote ubiquitination and subsequent degradation of the protein by the proteasome.