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43 articles in total
GLP-1 Peptide Lipidation: Chain, Linker, and Attachment Design
Fatty-acid-derived modification can introduce an albumin-binding handle, but the chain alone does not define the conjugate. Functional group identity, linker composition, attachment position, and the peptide sequence all influence what must be synthesized, purified, and measured.
CycDockAssem: A Reported Fragment Workflow for Cyclic Peptide Design
The paper describes a de novo workflow built around four structural fragments: two are positioned at selected regions of a protein surface, and two are used to connect the docked segments into a closed backbone. Candidate scaffolds then move through geometry-based ranking, fixed-backbone sequence redesign, and molecular-dynamics-based prioritization.
ADC Payload and Linker Design: A Chemistry Review Framework
ADC linker–payload design is a coupled optimization problem: payload function sets physicochemical and analytical demands, while the linker determines attachment, stability, and the chemical form released. A 2026 review by Samson Gebretnsae describes options ranging from established cytotoxic classes to emerging immune-stimulating, degradation, metabolic, and photoactivated concepts. For R&D teams, the useful output is not a rank order of modalities but a matrix of testable material attributes.
Reported Phosphorylated ADC Linker and DAR Design
Conventional ADC development often starts with antigen binding, linker stability, and cytotoxic payload release. A phosphorylated payload concept changes the payload question. The reported payload is not framed as a classic cytotoxin; it is framed as a polar phosphorylated molecule intended to support an intracellular recognition hypothesis.
Reported MK-0616 Route Analysis Highlights Peptide Biocatalysis
The reported retrosynthetic map treats MK-0616 as a fragment-intensive macrocyclic peptide program, with multiple non-natural amino acid building blocks that must be controlled before final assembly. That architecture shifts the development question from simple peptide coupling to building-block access, stereochemical control, impurity management, and fragment supply reliability.
Reported TFA Cleavage Tactics for Cys S-tert-Butylation in SPPS
In Fmoc/tBu solid-phase peptide synthesis, cysteine can become vulnerable during final acidic cleavage because side-chain protecting groups and resin cleavage chemistry generate reactive tert-butyl species. Reported process-development work describes S-tert-butylated cysteine as an impurity formed when tert-butyl cations re-attack deprotected Cys thiols during the TFA cleavage step.