5'-GalNAc C3 Phosphoramidite
Oligonucleotide Conjugation & Delivery Ligands
Product summary
Quick view
- Product family
- Oligonucleotide Conjugation & Delivery Ligands
- MF
- C62H88N5O17P
- MW
- 1206.4
- Purity
- >98%
5'-GalNAc C3 Phosphoramidite is a conjugate building block for installing an N-acetylgalactosamine ("GalNAc") ligand on an oligonucleotide. Its C3-linker scaffold carries a trimethoxytrityl (TMT)-protected hydroxymethyl group and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite. Key identifiers include CAS 2437303-51-8, molecular formula C62H88N5O17P, and molecular weight 1206.4 (PubChem CID 170903051).
The phosphoramidite installs GalNAc at the oligonucleotide 5'-terminus. Glen Research identifies TMT, not DMT, as the protecting group for this product line and demonstrates consecutive GalNAc-amidite additions after detritylation. GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
Synonyms
5'-GalNAc-C3 phosphoramidite; N-acetylgalactosamine C3-linker amidite
Identity and specifications
| Catalog No. | CH67005 |
| CAS No. | 2437303-51-8 |
| Molecular Formula | C62H88N5O17P |
| Molecular Weight | 1206.4 |
| PubChem CID | 170903051 |
| InChIKey | CBVYXTMIYQCOPE-KDYLSCEUSA-N |
| Purity | >98% |
Storage conditions
-20 +/- 5 C
Technical attributes
- Ligand
- N-Acetylgalactosamine (GalNAc)
- Linker
- C3
- Coupling group
- Phosphoramidite
- Oligonucleotide position
- 5'-Terminal modification
- Packaging
- 250 mg; 50 µmol; 100 µmol; Custom packaging on request
- Physical form
- white to light-yellow powder
Application context
- 5'-GalNAc conjugation: installs an N-acetylgalactosamine ligand on a C3 linker at the oligonucleotide 5'-terminus.
- Consecutive GalNAc additions: the TMT-protected hydroxymethyl group supports another GalNAc-amidite addition after detritylation.
- ASGPR ligand: GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
Related technical resources
Hepatocyte-Targeted Delivery
GalNAc ligands, oligo conjugation handles, lipid conjugates, and linker choices for liver-directed delivery research.
GalNAc vs Lipid Conjugation
Compare receptor-directed multivalent GalNAc and structure-dependent lipid conjugation as distinct oligonucleotide delivery strategies.
Public references
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem Compound 170903051
PubChem · CID 170903051
Frequently Asked Questions
What does this GalNAc phosphoramidite do?
It installs an N-acetylgalactosamine (GalNAc) ligand on a C3 linker at the oligonucleotide 5'-terminus. The scaffold carries a trimethoxytrityl (TMT)-protected hydroxymethyl group, which can be detritylated before another GalNAc-amidite addition.
What does GalNAc bind?
GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
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