MMT-C12-Amine-Linker Phosphoramidite
Oligonucleotide Conjugation & Delivery Ligands
Product summary
Quick view
- Product family
- Oligonucleotide Conjugation & Delivery Ligands
- MF
- C41H60N3O3P
- MW
- 673.9
- Purity
- 98%
MMT-C12-Amine-Linker Phosphoramidite is a non-nucleoside modifier for adding a reactive amino group to an oligonucleotide on a long spacer: a twelve-carbon (dodecyl) linker carrying a monomethoxytrityl (MMT)-protected primary amine at one end and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite at the other. Its PubChem-backed identity includes CAS 178925-51-4, molecular formula C41H60N3O3P, molecular weight 673.9, and PubChem CID 21918168.
Coupling attaches an aminododecyl arm to the oligonucleotide (typically the 5'-terminus). The acid-labile MMT group protects the amine during synthesis and is removed afterward to reveal a free primary amine on a C12 spacer. The cited amino-modifier literature describes aliphatic amino groups reacting with electrophiles, allowing dyes, biotin, or other chemical species to be attached; the C12 spacer is longer than the C6 analogue.
Synonyms
5'-Amino-Modifier C12; 12-(MMT-amino)dodecyl-(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidite
Identity and specifications
| Catalog No. | CH65105 |
| CAS No. | 178925-51-4 |
| Molecular Formula | C41H60N3O3P |
| Molecular Weight | 673.9 |
| PubChem CID | 21918168 |
| InChIKey | VJLVUDQTXLCFHR-UHFFFAOYSA-N |
| Purity | 98% |
Storage conditions
-20 C
Technical attributes
- Modifier type
- Non-nucleoside amino-modifier phosphoramidite
- Spacer
- C12 (dodecyl)
- Protecting group
- MMT (monomethoxytrityl), acid-labile
- Exposed handle
- Primary amine after MMT removal
- Grade
- Analytical grade
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 500 g; 1 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless oily liquid
- Stability
- Acetonitrile solution: use within 24 hours; SDS: stable
Application context
- Long-arm amino handle: provides a primary amine on a twelve-carbon spacer at the oligonucleotide terminus.
- Electrophile-reactive amine: the cited literature describes aliphatic amino groups reacting with electrophiles to attach dyes, biotin, or other species.
- MMT-protected during synthesis: the acid-labile MMT group masks the amine during assembly and is removed to expose it afterward.
Related technical resources
Hepatocyte-Targeted Delivery
GalNAc ligands, oligo conjugation handles, lipid conjugates, and linker choices for liver-directed delivery research.
GalNAc vs Lipid Conjugation
Compare receptor-directed multivalent GalNAc and structure-dependent lipid conjugation as distinct oligonucleotide delivery strategies.
Public references
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem Compound 21918168
PubChem · CID 21918168
Frequently Asked Questions
What does this amino-linker do, and how is it different from the C6 version?
It provides a primary amine at an oligonucleotide terminus for conjugation, the same as the C6 amino-modifier, but on a longer twelve-carbon spacer.
Why is the amine MMT-protected?
The monomethoxytrityl (MMT) group masks the reactive amine during solid-phase synthesis. It is acid-labile and removed afterward to reveal the free primary amine for conjugation with electrophiles.
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