2'-O-C16-C (Ac) Phosphoramidite
Oligonucleotide Conjugation & Delivery Ligands
Product summary
Quick view
- Product family
- Oligonucleotide Conjugation & Delivery Ligands
- MF
- C57H82N5O9P
- MW
- 1012.3
- Purity
- 99.98%
2'-O-C16-C (Ac) Phosphoramidite is a lipophilic 2'-modified RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N4-acetylcytidine with a 2'-O-hexadecyl (C16) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 2382942-38-1, molecular formula C57H82N5O9P, molecular weight 1012.3, and PubChem CID 166450490.
The 2'-O-C16 chain is a permanent 2'-O-modification — a long, fatty-acid-type lipophilic substituent rather than a protecting group. The cited 2'-modification literature discusses 2'-position sugar modifications in relation to nuclease/metabolic stability, and cited lipophilic-oligonucleotide literature discusses fatty-acid-type moieties in relation to lipid-particle and plasma-protein affinity. The monomer couples through a standard 3'-phosphoramidite (3'→5' linkages), the 5'-DMT is removed each cycle, and N4-acetyl protection is removed during final deprotection.
Synonyms
5'-O-DMT-N4-Ac-2'-O-hexadecylcytidine 3'-CE phosphoramidite; 2'-O-C16 (palmityl-type) cytidine amidite
Identity and specifications
| Catalog No. | CH65108 |
| CAS No. | 2382942-38-1 |
| Molecular Formula | C57H82N5O9P |
| Molecular Weight | 1012.3 |
| PubChem CID | 166450490 |
| InChIKey | NMBMTBHXQJMTLO-LCKVQZKFSA-N |
| Purity | 99.98% |
Storage conditions
-20 C
Technical attributes
- Modifier type
- Lipophilic nucleoside phosphoramidite
- Nucleoside scaffold
- Cytidine
- 2'-O substituent
- Hexadecyl (C16)
- Base protection
- N4-Acetyl
- Packaging
- 10 mg; 50 mg; 100 mg; 250 mg; 1 g; 2 g; 5 g; 10 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- 1 year under stated storage
Application context
- Lipophilic 2'-O-C16 modification: provides a long hexadecyl (C16) chain at the 2'-position — a permanent, fatty-acid-type lipophilic substituent.
- Cited 2'-modification context: the cited literature discusses 2'-position sugar modifications in relation to nuclease/metabolic stability.
- Cited lipophilic-moiety context: the cited literature discusses fatty-acid-type moieties in relation to lipid-particle and plasma-protein affinity.
- 3'→5' coupling monomer: couples through a 3'-phosphoramidite; 5'-DMT is removed each cycle; N4-acetyl protection is removed during final deprotection.
Public references
- PubChem Compound 166450490
PubChem · CID 166450490
Frequently Asked Questions
What is the 2'-O-C16 modification?
It is a 2'-O-hexadecyl group — a long, fatty-acid-type lipophilic chain permanently attached at the 2'-position. It is not a protecting group; it stays on the finished oligonucleotide.
What identifiers should match for CH65108?
Use CAS 2382942-38-1, molecular formula C57H82N5O9P, molecular weight 1012.3, and PubChem CID 166450490.
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