DOPE
Chemical Name
[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
DOPE•LNP
Structure: 
Product No
CH51011
CAS
4004-05-1
MF
C41H78NO8P
MW
744.05
Specification
| Catalog No. | CH51011 |
| CAS No. | 4004-05-1 |
| Molecular Formula | C41H78NO8P |
| Molecular Weight | 744.05 |
CHEMOS Support for This Category
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
Overview
DOPE (also known as [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate) (CAS 4004-05-1, MF C41H78NO8P, MW 744.05) belongs to the helper phospholipid class used in nucleic acid delivery system research and liposomal drug carriers. Typical chemistry topics include stereo-purity at the glycerol backbone, residual free fatty acid, and related diacyl regio-isomers. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
Applications
- DOPE (CAS 4004-05-1) preparation, route refinement, and analytical-control planning
- Helper phospholipid component in LNP and liposomal formulation research
- Pulmonary surfactant and biophysical research applications
- Process-development support for scalable phospholipid preparation
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