CHEMOS
DSPE-MPEG2000

DSPE-MPEG2000

Chemical Name

sodium [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate

DSPE-MPEG2000•LNP
Structure: DSPE-MPEG2000 structure, CAS 147867-65-0, MW 872.135911
Product No
CH51015
CAS
147867-65-0
MF
C45H87NNaO11P
MW
872.135911
Specification
Catalog No.CH51015
CAS No.147867-65-0
Molecular FormulaC45H87NNaO11P
Molecular Weight872.135911

CHEMOS Support for This Category

CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.

Overview

DSPE-MPEG2000 (also known as sodium [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate) (CAS 147867-65-0, MF C45H87NNaO11P, MW 872.135911) is a PEG-lipid conjugate used as a stealth or functional component in nucleic-acid delivery systems. Practical chemistry questions involve PEG repeat distribution, lipid anchor integrity, and terminal-group functionalisation strategy. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • DSPE-MPEG2000 (CAS 147867-65-0) preparation, route refinement, and analytical-control planning
  • Process-development support for scalable PEG-lipid preparation
  • Analytical method development for PEG-lipid characterisation
  • Stealth or functional PEG-lipid component in LNP / liposomal formulation research

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