DOTAP MeSO4
Chemical Name
DOTAP methyl sulfate
DOTAP MeSO4•LNP
Structure: 
Product No
CH51042
CAS
144189-73-1
MF
C43H83NO8S
MW
774.19
Specification
| Catalog No. | CH51042 |
| CAS No. | 144189-73-1 |
| Molecular Formula | C43H83NO8S |
| Molecular Weight | 774.19 |
CHEMOS Support for This Category
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
Overview
DOTAP MeSO4 (also known as DOTAP methyl sulfate) (CAS 144189-73-1, MF C43H83NO8S, MW 774.19) is an ionizable lipid analog studied in lipid nanoparticle (LNP) formulations for nucleic acid delivery research, including mRNA and siRNA platforms. Practical chemistry topics around this compound include head-group structure, ester or amine linker chemistry, and tail unsaturation. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
Applications
- DOTAP MeSO4 (144189-73-1) supply and analog preparation for research programs
- Custom analog synthesis with controlled head-group and tail variants
- Reference comparator in next-generation ionizable lipid programs
- Analytical method development for ionizable lipid related substances
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