CHEMOS
1,2-Di-DHA-sn-glycero-3-phosphocholine

1,2-Di-DHA-sn-glycero-3-phosphocholine

Chemical Name

1,2-Di(4,7,10,13,16,19-docosahexaenoyl)-sn-glycero-3-phosphocholine

1,2-Di-DHA-sn-glycero-3-phosphocholine•LNP
Structure: 1,2-Di-DHA-sn-glycero-3-phosphocholine structure, CAS 99296-81-8, MW 878.17
Product No
CH51060
CAS
99296-81-8
MF
C52H84NO8P
MW
878.17
Specification
Catalog No.CH51060
CAS No.99296-81-8
Molecular FormulaC52H84NO8P
Molecular Weight878.17

CHEMOS Support for This Category

CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.

Overview

1,2-Di-DHA-sn-glycero-3-phosphocholine (also known as 1,2-Di(4,7,10,13,16,19-docosahexaenoyl)-sn-glycero-3-phosphocholine) (CAS 99296-81-8, MF C52H84NO8P, MW 878.17) belongs to the helper phospholipid class used in nucleic acid delivery system research and liposomal drug carriers. Typical chemistry topics include stereo-purity at the glycerol backbone, residual free fatty acid, and related diacyl regio-isomers. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • 1,2-Di-DHA-sn-glycero-3-phosphocholine (CAS 99296-81-8) preparation, route refinement, and analytical-control planning
  • Bilayer-property studies in nucleic-acid delivery system development
  • Pulmonary surfactant and biophysical research applications
  • Custom synthesis of acyl-chain or head-group variants

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