CHEMOS
(S,R,S)-AHPC

(S,R,S)-AHPC

Chemical Name

(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(S,R,S)-AHPC•PROTAC
Structure: (S,R,S)-AHPC structure, CAS 1448297-52-6, MW 430.56
Product No
CH56013
CAS
1448297-52-6
MF
C22H30N4O3S
MW
430.56
Specification
Catalog No.CH56013
CAS No.1448297-52-6
Molecular FormulaC22H30N4O3S
Molecular Weight430.56

CHEMOS Support for This Category

CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.

Overview

(S,R,S)-AHPC (also known as (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide) (CAS 1448297-52-6, MF C22H30N4O3S, MW 430.56) belongs to the PROTAC building-block class (linker / E3 ligand / warhead). Programs working with this compound typically focus on coupling-handle compatibility, linker length / composition exploration, and impurity control. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • (S,R,S)-AHPC (1448297-52-6) supply and analog preparation for research programs
  • Process-development support for scalable building-block preparation
  • Reference material in targeted protein degradation chemistry programs
  • PROTAC building block — linker / E3-ligand / degrader handle

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