CHEMOS
Triethylene glycol bis(p-toluenesulfonate)

Triethylene glycol bis(p-toluenesulfonate)

Chemical Name

2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Triethylene glycol bis(p-toluenesulfonate)•PROTAC
Structure: Triethylene glycol bis(p-toluenesulfonate) structure, CAS 19249-03-7, MW 458.55
Product No
CH56018
CAS
19249-03-7
MF
C20H26O8S2
MW
458.55
Specification
Catalog No.CH56018
CAS No.19249-03-7
Molecular FormulaC20H26O8S2
Molecular Weight458.55

CHEMOS Support for This Category

CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.

Overview

Triethylene glycol bis(p-toluenesulfonate) (also known as 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate) (CAS 19249-03-7, MF C20H26O8S2, MW 458.55) is used as a PROTAC research building block in degrader chemistry. Typical chemistry questions involve route design for the bifunctional architecture, linker selection, and analytical control of residual reagents. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • Triethylene glycol bis(p-toluenesulfonate) (19249-03-7) as a starting point for downstream chemistry programs
  • Linker-length and composition exploration for degrader optimisation
  • Process-development support for scalable building-block preparation
  • PROTAC building block — linker / E3-ligand / degrader handle

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