5-Hexynoic acid
Chemical Name
hex-5-ynoic acid
5-Hexynoic acid•PROTAC
Structure: 
Product No
CH56019
CAS
53293-00-8
MF
C6H8O2
MW
112.13
Specification
| Catalog No. | CH56019 |
| CAS No. | 53293-00-8 |
| Molecular Formula | C6H8O2 |
| Molecular Weight | 112.13 |
CHEMOS Support for This Category
CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.
Overview
5-Hexynoic acid (also known as hex-5-ynoic acid) (CAS 53293-00-8, MF C6H8O2, MW 112.13) is a PROTAC research building block — typically a linker, E3-ligase ligand, or degrader handle. Practical chemistry topics include orthogonal protecting groups, modular linker chemistry, and stereo-purity at chiral centres. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.
Applications
- 5-Hexynoic acid (53293-00-8) supply and analog preparation for research programs
- Bifunctional degrader synthesis with orthogonal protecting groups
- Custom analog synthesis with controlled coupling handles
- Reference material in targeted protein degradation chemistry programs
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