JH-RE-06
JH-RE-06
Product summary
Quick view
- Product family
- PROTAC, E3 Ligands & Proximity-Inducing Building Blocks
- Chemical Name
- JH-RE-06
- MF
- C20H16Cl3N3O4
- MW
- 468.7
JH-RE-06 is a chlorinated nitroquinolinone compound identified by CAS 1361227-90-8.
The verified record matches molecular formula C20H16Cl3N3O4, molecular weight about 468.7, PubChem CID 70691604, and InChIKey LRTXIQCBQIKIOH-UHFFFAOYSA-N.
Published literature describes JH-RE-06 in REV1 inhibition research; the identifiers below keep that research tied to the confirmed compound identity.
Identity and specifications
| Catalog No. | CH57007 |
| CAS No. | 1361227-90-8 |
| Chemical Name | JH-RE-06 |
| Molecular Formula | C20H16Cl3N3O4 |
| Molecular Weight | 468.7 |
| PubChem CID | 70691604 |
| IUPAC Name | 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one |
| Synonyms | 8-chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one; CHEMBL2012449 |
| InChIKey | LRTXIQCBQIKIOH-UHFFFAOYSA-N |
Application context
- REV1 research: published records describe JH-RE-06 as a REV1 inhibitor research compound.
- Quinolinone identity reference: supports comparison of the chlorinated anilino, nitro, and quinolinone structural features.
- Catalog data alignment: helps keep CAS 1361227-90-8, formula C20H16Cl3N3O4, PubChem CID 70691604, and InChIKey LRTXIQCBQIKIOH-UHFFFAOYSA-N consistent across records.
Additional material information
Characteristics
- Chlorinated nitroquinolinone structure with a 2,4-dichloroanilino substituent.
- Halogenated nitrogen-containing compound with formula C20H16Cl3N3O4.
- CAS and name lookups both resolve to PubChem CID 70691604.
Related technical resources
PROTAC / TPD Building Blocks
CRBN and VHL ligand derivatives, ligand-linkers, bifunctional degrader intermediates, and linker-tuning building blocks.
PROTAC Linker Selection
Build linker series from both ligands, exit vectors, ternary-complex geometry, conformation, permeability, synthesis, and assay evidence.
Public references
- 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one | PubChem CID 70691604
- Catalytic in vivo protein knockdown by small-molecule PROTACs
Nature Chemical Biology, 2015
Product-family technical context
- Structural basis of PROTAC cooperative recognition for selective protein degradation
Nature Chemical Biology, 2017
Product-family technical context
- Structural Basis of PROTAC Cooperative Recognition for Selective Protein Degradation
Nature Chemical Biology, 2017
Product-family technical context
- Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
ACS Medicinal Chemistry Letters, 2022
Product-family technical context
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.