JH-RE-06
Chemical Name
8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one
JH-RE-06•Molecular Glues
Structure: 
Product No
CH57007
CAS
1361227-90-8
MF
C20H16Cl3N3O4
MW
468.72
Specification
| Catalog No. | CH57007 |
| CAS No. | 1361227-90-8 |
| Molecular Formula | C20H16Cl3N3O4 |
| Molecular Weight | 468.72 |
CHEMOS Support for This Category
CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.
Overview
JH-RE-06 (also known as 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one) (CAS 1361227-90-8, MF C20H16Cl3N3O4, MW 468.72) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
Applications
- JH-RE-06 (1361227-90-8) as a starting point for downstream chemistry programs
- Analog screening for E3-ligase recruitment chemistry
- Custom synthesis of analog series for SAR exploration
- Process-development support for scalable scaffold preparation
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