HQ461
HQ461
Product summary
Quick view
- Product family
- PROTAC, E3 Ligands & Proximity-Inducing Building Blocks
- Chemical Name
- HQ461
- MF
- C15H15N5OS2
- MW
- 345.4
HQ461 is a thiazole-containing acetamide compound identified by CAS 1226443-41-9.
The verified record matches molecular formula C15H15N5OS2, molecular weight about 345.4, PubChem CID 49677967, and InChIKey QMRBCNQCRMTXBE-UHFFFAOYSA-N.
Published literature places HQ461 in molecular-glue research involving CDK12-DDB1 interaction and cyclin K degradation; the identifiers below keep that context tied to the confirmed compound identity.
Identity and specifications
| Catalog No. | CH57011 |
| CAS No. | 1226443-41-9 |
| Chemical Name | HQ461 |
| Molecular Formula | C15H15N5OS2 |
| Molecular Weight | 345.4 |
| PubChem CID | 49677967 |
| IUPAC Name | 2-[2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide |
| Synonyms | HQ-461; HQ 461; CHEMBL5175040 |
| InChIKey | QMRBCNQCRMTXBE-UHFFFAOYSA-N |
Application context
- CDK12-DDB1 research: published records discuss HQ461 in molecular-glue research involving CDK12-DDB1 interaction.
- Cyclin K research background: literature records associate HQ461 with cyclin K degradation research.
- Catalog data alignment: helps keep CAS 1226443-41-9, formula C15H15N5OS2, PubChem CID 49677967, and InChIKey QMRBCNQCRMTXBE-UHFFFAOYSA-N consistent across records.
Additional material information
Characteristics
- Thiazole-containing acetamide structure with a methylpyridinyl amino substituent.
- Nitrogen- and sulfur-containing heteroaromatic compound with formula C15H15N5OS2.
- CAS and name lookups both resolve to PubChem CID 49677967.
Related technical resources
PROTAC / TPD Building Blocks
CRBN and VHL ligand derivatives, ligand-linkers, bifunctional degrader intermediates, and linker-tuning building blocks.
PROTAC Linker Selection
Build linker series from both ligands, exit vectors, ternary-complex geometry, conformation, permeability, synthesis, and assay evidence.
Public references
- 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide | PubChem CID 49677967
- Catalytic in vivo protein knockdown by small-molecule PROTACs
Nature Chemical Biology, 2015
Product-family technical context
- Structural basis of PROTAC cooperative recognition for selective protein degradation
Nature Chemical Biology, 2017
Product-family technical context
- Structural Basis of PROTAC Cooperative Recognition for Selective Protein Degradation
Nature Chemical Biology, 2017
Product-family technical context
- Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
ACS Medicinal Chemistry Letters, 2022
Product-family technical context
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