CHEMOS
HQ461

HQ461

Chemical Name

2-[2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide

HQ461•Molecular Glues
Structure: HQ461 structure, CAS 1226443-41-9, MW 345.44
Product No
CH57011
CAS
1226443-41-9
MF
C15H15N5OS2
MW
345.44
Specification
Catalog No.CH57011
CAS No.1226443-41-9
Molecular FormulaC15H15N5OS2
Molecular Weight345.44

CHEMOS Support for This Category

CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.

Overview

HQ461 (also known as 2-[2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide) (CAS 1226443-41-9, MF C15H15N5OS2, MW 345.44) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • HQ461 (CAS 1226443-41-9) preparation, route refinement, and analytical-control planning
  • Molecular glue research scaffold for targeted protein degradation
  • Custom synthesis of analog series for SAR exploration
  • Reference research scaffold in degrader chemistry programs

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