CHEMOS
EN171

EN171

Chemical Name

1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one

EN171•Molecular Glues
Structure: EN171 structure, CAS 2191110-79-7, MW 270.37
Product No
CH57013
CAS
2191110-79-7
MF
C17H22N2O
MW
270.37
Specification
Catalog No.CH57013
CAS No.2191110-79-7
Molecular FormulaC17H22N2O
Molecular Weight270.37

CHEMOS Support for This Category

CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.

Overview

EN171 (also known as 1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one) (CAS 2191110-79-7, MF C17H22N2O, MW 270.37) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • EN171 (CAS 2191110-79-7) route review and custom analog preparation
  • Custom synthesis of analog series for SAR exploration
  • Reference research scaffold in degrader chemistry programs
  • Analog screening for E3-ligase recruitment chemistry

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