EN171
EN171
Product summary
Quick view
- Product family
- PROTAC, E3 Ligands & Proximity-Inducing Building Blocks
- Chemical Name
- EN171
- MF
- C17H22N2O
- MW
- 270.37
EN171 is a benzyl diazaspiro compound identified by CAS 2191110-79-7.
The verified record matches molecular formula C17H22N2O, molecular weight 270.37, PubChem CID 132317810, and InChIKey VKQVCQHCQMFBNJ-UHFFFAOYSA-N.
Published literature places EN171 in covalent 14-3-3 recruitment and molecular-glue research discussions; the identifiers below keep that context tied to the confirmed compound identity.
Identity and specifications
| Catalog No. | CH57013 |
| CAS No. | 2191110-79-7 |
| Chemical Name | EN171 |
| Molecular Formula | C17H22N2O |
| Molecular Weight | 270.37 |
| PubChem CID | 132317810 |
| IUPAC Name | 1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one |
| Synonyms | 1-{7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one; CHEMBL6170086 |
| InChIKey | VKQVCQHCQMFBNJ-UHFFFAOYSA-N |
Application context
- Covalent 14-3-3 recruitment research: published records describe EN171 in covalent 14-3-3 recruitment studies.
- Molecular-glue research background: literature records associate EN171 with molecular-glue research involving 14-3-3 systems.
- Catalog data alignment: helps keep CAS 2191110-79-7, formula C17H22N2O, PubChem CID 132317810, and InChIKey VKQVCQHCQMFBNJ-UHFFFAOYSA-N consistent across records.
Additional material information
Characteristics
- Benzyl diazaspiro[4.4]nonane framework connected to a prop-2-en-1-one group.
- Nitrogen-containing spiro compound with formula C17H22N2O.
- CAS and name lookups both resolve to PubChem CID 132317810.
Related technical resources
PROTAC / TPD Building Blocks
CRBN and VHL ligand derivatives, ligand-linkers, bifunctional degrader intermediates, and linker-tuning building blocks.
PROTAC Linker Selection
Build linker series from both ligands, exit vectors, ternary-complex geometry, conformation, permeability, synthesis, and assay evidence.
Public references
- 1-{7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one | PubChem CID 132317810
- Catalytic in vivo protein knockdown by small-molecule PROTACs
Nature Chemical Biology, 2015
Product-family technical context
- Structural basis of PROTAC cooperative recognition for selective protein degradation
Nature Chemical Biology, 2017
Product-family technical context
- Structural Basis of PROTAC Cooperative Recognition for Selective Protein Degradation
Nature Chemical Biology, 2017
Product-family technical context
- Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
ACS Medicinal Chemistry Letters, 2022
Product-family technical context
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