CHEMOS
IKZF2-degrader 2

IKZF2-degrader 2

Chemical Name

3-[6-[5-chloro-1-methyl-4-(pyrrolidin-1-ylmethyl)pyrrolo[2,3-b]pyridin-6-yl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

IKZF2-degrader 2•Molecular Glues
Structure: IKZF2-degrader 2 structure, CAS 2983841-00-3, MW 509.96
Product No
CH57017
CAS
2983841-00-3
MF
C26H25ClFN5O3
MW
509.96
Specification
Catalog No.CH57017
CAS No.2983841-00-3
Molecular FormulaC26H25ClFN5O3
Molecular Weight509.96

CHEMOS Support for This Category

CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.

Overview

IKZF2-degrader 2 (also known as 3-[6-[5-chloro-1-methyl-4-(pyrrolidin-1-ylmethyl)pyrrolo[2,3-b]pyridin-6-yl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione) (CAS 2983841-00-3, MF C26H25ClFN5O3, MW 509.96) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • IKZF2-degrader 2 (CAS 2983841-00-3) preparation, route refinement, and analytical-control planning
  • Custom synthesis of analog series for SAR exploration
  • Process-development support for scalable scaffold preparation
  • Reference research scaffold in degrader chemistry programs

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