2'-O-NMA-A (Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C50H57N8O9P
- MW
- 945.0
- Purity
- >=98% (HPLC)
2'-O-NMA-A (Bz) CE Phosphoramidite is a 2'-modified RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine with a 2'-O-[2-(methylamino)-2-oxoethyl] group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 1025783-20-3, molecular formula C50H57N8O9P, molecular weight 945.0, PubChem CID 168440831, and InChIKey GEYNOJIHDLPUEX-GNUXOQNYSA-N.
"NMA" denotes the 2'-O-N-methylacetamide group (2'-O-CH2-C(=O)-NH-CH3), a permanent 2'-O-modification rather than a protecting group. The cited 2'-modification literature is used here as background for the 2'-position modification class, not as a standalone performance claim for this catalog item. The monomer couples through a standard 3'-phosphoramidite (3'→5' linkages), the 5'-DMT is removed each cycle, and the N6-benzoyl base-protecting group is removed during final deprotection.
Synonyms
5'-O-DMT-N6-Bz-2'-O-[2-(methylamino)-2-oxoethyl]adenosine 3'-CE phosphoramidite; 2'-O-(N-methylcarbamoylmethyl)-adenosine amidite
Identity and specifications
| Catalog No. | CH65082 |
| CAS No. | 1025783-20-3 |
| Molecular Formula | C50H57N8O9P |
| Molecular Weight | 945.0 |
| PubChem CID | 168440831 |
| InChIKey | GEYNOJIHDLPUEX-GNUXOQNYSA-N |
| Purity | >=98% (HPLC) |
Storage conditions
<=-20 C
Technical attributes
- Monomer class
- 2'-O-NMA CE phosphoramidite
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-(N-methylacetamide)
- Base protection
- N6-benzoyl
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white or off-white to faint yellow powder
- Stability
- stable under recommended storage conditions
Application context
- 2'-O-N-methylacetamide (NMA) modification: a permanent 2'-O-amide substituent at the 2'-position.
- 2'-modification literature context: the cited literature supports the broader 2'-position modification class; avoid rewriting it as a standalone performance claim for this catalog item.
- 3'→5' coupling monomer: the 3'-phosphoramidite couples to form 3'→5' linkages; the 5'-DMT is removed each cycle and the N6-benzoyl base-protecting group is removed during final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 168440831
PubChem · CID 168440831
Frequently Asked Questions
What does 'NMA' stand for in this monomer?
NMA is the 2'-O-N-methylacetamide group — a 2'-O-CH₂-C(=O)-NH-CH₃ substituent (2'-O-[2-(methylamino)-2-oxoethyl]). It is a permanent 2'-O-modification, not a protecting group.
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