Ac4ManNAz
[(2R,3S,4R,5S)-3,4,6-triacetyloxy-5-[(2-azidoacetyl)amino]oxan-2-yl]methyl acetate
Product summary
Quick view
- Product family
- Click Chemistry & Bioconjugation Reagents
- Chemical Name
- [(2R,3S,4R,5S)-3,4,6-triacetyloxy-5-[(2-azidoacetyl)amino]oxan-2-yl]methyl acetate
- MF
- C16H22N4O10
- MW
- 430.37
- Purity
- 99.80000% (HPLC)
Ac4ManNAz is a tetraacetylated N-azidoacetylmannosamine derivative used as a ManNAz metabolic glycan reporter in research workflows involving azido-modified sialic-acid glycans. PubChem records it as CID 71311757, CAS 361154-30-5, molecular formula C16H22N4O10, molecular weight 430.37, exact mass 430.13359291, and InChIKey HGMISDAXLUIXKM-LIADDWGISA-N.
The acetylated ManNAz scaffold supports metabolic glycan-engineering studies, while the azide handle enables downstream bioorthogonal tagging with suitable alkyne probes in analytical glycan-labeling workflows.
Synonyms
Ac4ManNAz; 1,3,4,6-tetra-O-acetyl-N-azidoacetylmannosamine; tetraacetylated N-azidoacetylmannosamine; ManNAz tetraacetate
Identity and specifications
| Catalog No. | CH70476 |
| Product Name | Ac4ManNAz |
| CAS No. | 361154-30-5 |
| Molecular Formula | C16H22N4O10 |
| Molecular Weight | 430.37 |
| Exact Mass | 430.13359291 |
| PubChem CID | 71311757 |
| InChIKey | HGMISDAXLUIXKM-LIADDWGISA-N |
| Synonyms | 1,3,4,6-tetra-O-acetyl-N-azidoacetylmannosamine; ManNAz tetraacetate |
| Purity | 99.80000% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Sugar scaffold
- N-acetylmannosamine analog
- Sugar protection
- Tetra-O-acetyl
- Chemical-reporter handle
- N-azidoacetyl group
- Labeling role
- Metabolic glycan reporter precursor
- Packaging
- 5 mg; 100 mg; 5 x 5 mg; Custom packaging on request
- Physical form
- Solid
- Stability
- >=4 years
Application context
- Metabolic glycan-engineering research: Ac4ManNAz is a ManNAz tetraacetate reporter used in studies involving azido-modified sialic-acid glycans.
- Bioorthogonal tagging workflows: the azide handle supports downstream ligation with compatible alkyne probes for detection, enrichment, or imaging workflows in research settings.
- Analytical glycomics context: Ac4ManNAz is relevant to workflows that label sialylated glycans before downstream analysis of glycoconjugates or sialoglycoproteins.
Additional material information
Uses
Use in research workflows that require a ManNAz-derived azido sugar reporter for studying azido-modified sialic-acid glycans and related glycoconjugates. Keep interpretation tied to the experimental system and analytical controls.
Characteristics
Ac4ManNAz combines a protected ManNAz sugar scaffold with an azidoacetyl reporter handle. The tetraacetylated form is used in metabolic glycan-engineering workflows, and the azide supports downstream bioorthogonal tagging with compatible alkyne probes.
Related technical resources
Public references
- A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems
Journal of the American Chemical Society, 2004
Product-family technical context
- Copper-free click chemistry for dynamic in vivo imaging
Proceedings of the National Academy of Sciences, 2007
Product-family technical context
- A Strain-Promoted [3 + 2] Azide–Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems
Journal of the American Chemical Society, 2004
Product-family technical context
- Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels–Alder Reactivity
Journal of the American Chemical Society, 2008
Product-family technical context
- PubChem Compound 71311757
PubChem · CID 71311757
Frequently Asked Questions
What is Ac4ManNAz?
Ac4ManNAz is a tetraacetylated N-azidoacetylmannosamine derivative, also described as ManNAz tetraacetate. PubChem records it as CID 71311757 with CAS 361154-30-5.
How is Ac4ManNAz used in research workflows?
It is used as a ManNAz metabolic glycan reporter in research workflows involving azido-modified sialic-acid glycans. The azide handle can be paired with compatible alkyne probes for downstream bioorthogonal tagging.
Is Ac4ManNAz the same as Ac4GlcNAz?
No. Ac4ManNAz and Ac4GlcNAz share the same molecular formula but differ by sugar stereochemistry and PubChem identity. Ac4ManNAz is the ManNAz tetraacetate reporter for sialic-acid glycan workflows.
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