NOTA

NOTA (1,4,7-triazacyclononane-triacetic acid) is a macrocyclic chelating agent commonly used for coordinating radiometals in diagnostic imaging probes. Its compact ring structure allows efficient complexation with metal ions such as gallium and copper isotopes. The resulting metal complexes exhibit high stability, making NOTA a reliable chelator for labeling biomolecules used in positron emission tomography (PET) and other molecular imaging techniques.

NOTA chelators are particularly suited for short-lived radionuclides due to their rapid radiolabeling kinetics and mild labeling conditions. These features support efficient production of imaging agents with high radiochemical purity and stability. As molecular imaging technologies advance, optimized NOTA derivatives continue to expand the capabilities of precision diagnostics and targeted radiopharmaceutical development.

Product List

Catalog No.	Name	CAS No.	Structure	M.W.
CH55001	NOTA-NHS ester	1338231-09-6		400.38
CH55002	Maleimide-NOTA	1295584-83-6		425.44
CH55003	NOTA	56491-86-2		303.31
CH55004	p-SCN-Bn-NOTA trihydrochloride	1583289-85-3		559.89
CH55005	NOTA-bis(tBu)ester	1161415-28-6		415.52
CH55006	NOTA-FAPI	2374782-03-1		771.82
CH55007	p-NCS-Bz-NODA-GA	1660127-21-8		521.59
CH55008	MMA-NODAGA	1440903-11-6		497.51
CH55009	NO2A-Butyne	2089035-56-1		354.4
CH55010	NO2A-Azide trihydrochloride	2435782-92-4	N/A	494.8

Technical Questions

Frequently Asked Questions

Common questions about custom synthesis, process development, analytical information, and project discussion for NOTA.

Why is NOTA often used for Ga and Cu radiochemistry?

NOTA has a compact macrocyclic cavity and relatively fast radiolabeling kinetics with metals such as Ga and Cu. This makes it useful in many PET tracer research workflows.

What is the difference between NOTA and NODAGA?

NODAGA introduces a glutaric acid side arm for conjugation while retaining the NOTA chelation motif. It is often selected when a linker-ready NOTA-family building block is needed.

Can CHEMOS support custom NOTA or NODAGA derivatives?

CHEMOS can review protected, activated, and conjugation-ready NOTA-family intermediates according to the target structure and project requirements.

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