DOTA

DOTA (tetraazacyclododecanetetraacetic acid) is a macrocyclic chelator widely used for coordinating metal ions in radiopharmaceuticals and targeted imaging agents. Its macrocyclic structure contains four nitrogen atoms and four carboxylate groups that form highly stable complexes with a variety of metal ions, including lanthanides and therapeutic radionuclides. This strong coordination chemistry enables reliable attachment of radioactive metals to biomolecules such as peptides, antibodies, or small molecules.

Due to its exceptional thermodynamic stability and kinetic inertness, DOTA has become a standard chelator in the development of targeted radiopharmaceuticals. It is widely used in molecular imaging and radionuclide therapy platforms, supporting applications such as diagnostic imaging and targeted radiotherapy. Continuous innovations in chelator design are further improving radiolabeling efficiency and enabling more precise theranostic strategies.

Product List

Catalog No.	Name	CAS No.	M.W.
CH54001	DOTA-tri(t-butyl ester)	137076-54-1	572.73
CH54002	DOTAGA-anhydride	1375475-53-8	458.46
CH54003	DOTA-GA-maleimide	1800229-46-2	598.61
CH54004	NH2-PEG4-DOTA	2090232-34-9	622.71
CH54005	2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)	173308-19-5	614.82
CH54006	DOTA-GA(tBu)4	306776-79-4	700.9
CH54007	Azido-mono-amide-DOTA	1227407-76-2	486.53
CH54008	NH2 DOTA-GA	1639843-65-4	518.57
CH54009	Butyne-DOTA	2125661-62-1	455.51
CH54010	DOTAM-mono-acid	913528-04-8	401.46

Technical Questions

Frequently Asked Questions

Common questions about custom synthesis, process development, analytical information, and project discussion for DOTA.

Which radiometals does DOTA chelate?

DOTA is widely studied with Y, Lu, In, Ga, Cu, Bi, and lanthanide ions. The appropriate chelator and labeling conditions depend on the selected metal, biomolecule, and research application.

When should I choose DOTA vs NOTA?

DOTA is often selected for larger trivalent metals and lanthanide-related systems, while NOTA is commonly used for smaller metals such as Ga and Cu where faster labeling kinetics may be preferred.

How is DOTA-NHS ester stored?

DOTA-NHS ester is moisture-sensitive. Storage and handling should follow the batch-specific COA or technical note, and users should minimize exposure to moisture during weighing and solution preparation.

Can CHEMOS support custom DOTA building blocks?

CHEMOS can review custom DOTA derivatives, activated esters, PEG-spaced variants, and chelator-linker intermediates according to the target structure and analytical requirements.

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