Tetrabenzyl pyrophosphate
dibenzyl bis(phenylmethoxy)phosphoryl phosphate
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- dibenzyl bis(phenylmethoxy)phosphoryl phosphate
- MF
- C28H28O7P2
- MW
- 538.47
- Purity
- 99.5%
Tetrabenzyl pyrophosphate is a protected pyrophosphate reagent also indexed as tetrabenzyl diphosphate, pyrophosphoric acid tetrabenzyl ester, diphosphoric acid tetrabenzyl ester, and benzyl pyrophosphate.
CH61002 is listed with CAS 990-91-0, molecular formula C28H28O7P2, and molecular weight 538.47. Research literature links tetrabenzyl pyrophosphate with chemoselective phosphorylation, phosphate synthesis, phosphodiester and phosphoramidate library workflows, protected glycosyl phosphate linkage formation, nucleotide-sugar derivative synthesis, and lead-ion responsive neutral-carrier research.
Synonyms
Tetrabenzyl pyrophosphate; Tetrabenzyl diphosphate; Pyrophosphoric acid tetrabenzyl ester; Diphosphoric acid tetrabenzyl ester; P,P,P',P'-Tetrakis(phenylmethyl) diphosphate; Benzyl pyrophosphate; Fosaprepitant Impurity S
Identity and specifications
| Catalog No. | CH61002 |
| CAS No. | 990-91-0 |
| Molecular Formula | C28H28O7P2 |
| Molecular Weight | 538.47 |
| PubChem CID | 563183 |
| InChIKey | NSBNXCZCLRBQTA-UHFFFAOYSA-N |
| Purity | 99.5% |
Storage conditions
Frozen below 0 C; under inert gas
Technical attributes
- Reagent class
- Protected pyrophosphate
- Phosphate protection
- Tetrabenzyl
- Phosphorus motif
- Pyrophosphate (P-O-P)
- Supported synthesis role
- Chemoselective phosphorylation reagent
- Packaging
- 1 g glass bottle with plastic insert; 100 kg batch; Custom packaging on request
- Water content
- Specification <=0.5%; result 0.12%
- Physical form
- Solid
- Stability
- Produced 2024-02-20; expiry 2026-02-20
Application context
- Phosphate synthesis: reported as a protected pyrophosphate reagent in chemoselective phosphorylation and debenzylation workflows.
- Phosphodiester and phosphoramidate workflows: reported in late-stage divergent synthesis of phosphodiester and phosphoramidate libraries.
- Glycosyl phosphate and nucleotide-sugar chemistry: aligned with protected glycosyl phosphate linkage formation and cytidine-diphosphate sugar derivative synthesis.
- Lead-ion carrier research: reported as a neutral carrier responsive to lead ion in analytical chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 563183
PubChem · CID 563183
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