(S)-GNA-A(Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C45H50N7O6P
- MW
- 815.9
- Purity
- >=98.0% (HPLC)
(S)-GNA-A(Bz) CE Phosphoramidite is the glycol nucleic acid (GNA) adenine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing an N6-benzoyl adenine, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65055 is identified by CAS 851050-24-3, molecular formula C45H50N7O6P, molecular weight 815.9, PubChem CID 102511305, and InChIKey RHPZFMWWZNRHHT-MXHUVDEASA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain, the acid-labile DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
Synonyms
(S)-GNA-A(Bz) phosphoramidite; DMT-(S)-glycol-N6-benzoyladenine CE phosphoramidite
Identity and specifications
| Catalog No. | CH65055 |
| CAS No. | 851050-24-3 |
| Molecular Formula | C45H50N7O6P |
| Molecular Weight | 815.9 |
| PubChem CID | 102511305 |
| InChIKey | RHPZFMWWZNRHHT-MXHUVDEASA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Adenine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- N6-benzoyl
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
Application context
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- DMT + N6-benzoyl protection: the acid-labile DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102511305
PubChem · CID 102511305
Frequently Asked Questions
What residue identity does this GNA amidite provide?
It provides the (S)-GNA adenine residue identity through its phosphoramidite coupling group, with DMT removed each cycle and N6-benzoyl removed at final deprotection.
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