(S)-GNA-C(Ac) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C39H48N5O7P
- MW
- 729.8
- Purity
- >=98.0% (HPLC)
(S)-GNA-C(Ac) CE Phosphoramidite is the glycol nucleic acid (GNA) cytosine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing an N4-acetyl cytosine, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65056 is identified by CAS 1159174-80-7, molecular formula C39H48N5O7P, molecular weight 729.8, PubChem CID 44196022, and InChIKey GJBIWQXFRRQYML-RRUDDRBXSA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain, the acid-labile DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
Synonyms
(S)-GNA-C(Ac) phosphoramidite; DMT-(S)-glycol-N4-acetylcytosine CE phosphoramidite
Identity and specifications
| Catalog No. | CH65056 |
| CAS No. | 1159174-80-7 |
| Molecular Formula | C39H48N5O7P |
| Molecular Weight | 729.8 |
| PubChem CID | 44196022 |
| InChIKey | GJBIWQXFRRQYML-RRUDDRBXSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Cytosine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- N4-acetyl
- Grade
- N (Normal)
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 3 years; in solvent 1 year
Application context
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- DMT + N4-acetyl protection: the acid-labile DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 44196022
PubChem · CID 44196022
Frequently Asked Questions
How does it differ from the (S)-GNA-A(Bz) amidite?
Both are (S)-GNA phosphoramidites, but this one has an N4-acetyl-protected cytosine, whereas the (S)-GNA-A(Bz) amidite has an N6-benzoyl adenine. Each GNA base is cataloged separately.
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