(S)-GNA-T CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C38H47N4O7P
- MW
- 702.8
- Purity
- >=99% (HPLC)
(S)-GNA-T CE Phosphoramidite is the glycol nucleic acid (GNA) thymine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing a thymine base, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65058 is identified by CAS 168332-13-6, molecular formula C38H47N4O7P, molecular weight 702.8, PubChem CID 102511306, and InChIKey RIVAXSKTYGDAOA-NMIPJSAASA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain and the acid-labile DMT is removed each cycle. Because thymine has no exocyclic amine, no base protecting group is required.
Synonyms
(S)-GNA-T phosphoramidite; DMT-(S)-glycol-thymine CE phosphoramidite
Identity and specifications
| Catalog No. | CH65058 |
| CAS No. | 168332-13-6 |
| Molecular Formula | C38H47N4O7P |
| Molecular Weight | 702.8 |
| PubChem CID | 102511306 |
| InChIKey | RIVAXSKTYGDAOA-NMIPJSAASA-N |
| Purity | >=99% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Thymine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- None required
- Grade
- N (Normal)
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 25 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 2 years
Application context
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- No base protection needed: thymine has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile DMT, removed each cycle).
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102511306
PubChem · CID 102511306
Frequently Asked Questions
Why does the GNA-T amidite have no base protecting group?
Thymine has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile DMT group (removed each cycle) and the reactive phosphoramidite coupling group.
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