2'-Deoxyinosine
9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Nombre químico
- 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
- FM
- C10H12N4O4
- PM
- 252.23
- Pureza
- >98.0% (HPLC, titration)
2'-Deoxyinosine (dI) is the purine DNA nucleoside built from hypoxanthine and 2-deoxy-β-D-ribose. CH64006 is listed under CAS 890-38-0, molecular formula C10H12N4O4, molecular weight 252.23, and PubChem CID 135398593.
This record is distinct from inosine, the corresponding RNA nucleoside. Deoxyinosine is used as a universal-base residue in degenerate primer and probe design, and incorporated hypoxanthine provides an endonuclease V recognition site for nucleic-acid amplification decontamination studies.
Sinónimos
2'-Deoxyinosine; deoxyinosine; dI; hypoxanthine 2'-deoxyriboside
Identidad y especificaciones
| Catalog No. | CH64006 |
| CAS No. | 890-38-0 |
| Molecular Formula | C10H12N4O4 |
| Molecular Weight | 252.23 |
| PubChem CID | 135398593 |
| InChIKey | VGONTNSXDCQUGY-RRKCRQDMSA-N |
| Purity | >98.0% (HPLC, titration) |
Condiciones de almacenamiento
-20 C
Atributos técnicos
- Nucleobase
- Hypoxanthine
- Sugar
- 2'-Deoxyribose
- Nucleoside class
- Purine 2'-deoxyribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Physical form
- Crystalline solid
- Stability
- >=4 years
Contexto de aplicación
- Degenerate primer and probe design: deoxyinosine pairs with all four canonical bases, and nearest-neighbor parameters are used in degenerate PCR-primer and microarray-probe design research.
- Endonuclease V decontamination studies: incorporated hypoxanthine from dI is recognized by endonuclease V in carryover-amplicon cleavage methods.
- dI nucleoside reference: CH64006 provides the deoxyinosine identity for nucleoside and oligonucleotide chemistry comparisons.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 135398593
PubChem · CID 135398593
Preguntas frecuentes
Why is deoxyinosine called a universal base?
Deoxyinosine (dI) pairs with all four canonical bases (C, A, T, G) with relatively low discrimination, so it is used as a universal-base position in degenerate primers and probes.
How is deoxyinosine used in amplification decontamination?
When deoxyinosine is incorporated, the resulting hypoxanthine is the recognition site for endonuclease V, which cleaves carryover amplicons while leaving the intended template intact.
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