N4-Isobutyryl-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C13H19N3O5
- PM
- 297.31
- Pureza
- >=99%
N4-Isobutyryl-2'-deoxycytidine (dCiBu) is 2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an isobutyryl group. CH64077 is identified by CAS 110522-75-3, molecular formula C13H19N3O5, molecular weight 297.31, PubChem CID 688503, and InChIKey PDTIVAGPIHEWDX-IQJOONFLSA-N.
The cited oligonucleotide-synthesis literature discusses isobutyryl as a labile cytosine base-protecting group and describes removal of base-protecting groups during deprotection. CH64077 provides the N4-isobutyryl-protected 2'-deoxycytidine identity for DNA building-block and nucleoside chemistry research.
Sinónimos
N4-Isobutyryl-2'-deoxycytidine; N4-ibu-dC; dCiBu
Identidad y especificaciones
| Catalog No. | CH64077 |
| CAS No. | 110522-75-3 |
| Molecular Formula | C13H19N3O5 |
| Molecular Weight | 297.31 |
| PubChem CID | 688503 |
| InChIKey | PDTIVAGPIHEWDX-IQJOONFLSA-N |
| Purity | >=99% |
Condiciones de almacenamiento
0-8 C
Atributos técnicos
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- Base protection
- N4-Isobutyryl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 1 g; 5 g; 10 g; 25 g; Custom packaging on request
- Physical form
- white powder
Contexto de aplicación
- Base-protected DNA building block: the N4-isobutyryl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Cytosine (dC) monomer precursor context: CH64077 is the isobutyryl-protected 2'-deoxycytidine identity relevant to cytosine building-block preparation.
- Nucleoside chemistry reference: CH64077 provides the N4-isobutyryl-2'-deoxycytidine (dCiBu) identity for nucleoside chemistry research.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 688503
PubChem · CID 688503
Preguntas frecuentes
Why is the N4-amine of this deoxycytidine protected with isobutyryl?
In oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a labile protecting group such as isobutyryl (a fast-deprotection cytosine protection); the group is later removed during deprotection.
How does it differ from N4-benzoyl- or N4-acetyl-2'-deoxycytidine?
All three protect the cytosine N4-amine, but with different acyl groups (isobutyryl, benzoyl, or acetyl). The benzoyl and acetyl forms are cataloged separately.
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