N2-(Dimethylaminomethylene)-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C13H18N6O4
- PM
- 322.32
- Pureza
- >=98.0% (HPLC)
N2-(Dimethylaminomethylene)-2'-deoxyguanosine (dmf-dG) is 2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with a dimethylformamidine (dmf) group. CH64078 is identified by CAS 17331-13-4, molecular formula C13H18N6O4, molecular weight 322.32, PubChem CID 135882612, and InChIKey ZXECVVVXPHBGGX-DJLDLDEBSA-N.
The cited oligonucleotide-synthesis literature discusses dimethylformamidine as a labile guanine base-protecting group and describes removal of base-protecting groups during deprotection. CH64078 provides the N2-dmf-protected 2'-deoxyguanosine identity for DNA building-block and nucleoside chemistry research.
Sinónimos
N2-(Dimethylaminomethylene)-2'-deoxyguanosine; N2-dmf-dG; dG(dmf)
Identidad y especificaciones
| Catalog No. | CH64078 |
| CAS No. | 17331-13-4 |
| Molecular Formula | C13H18N6O4 |
| Molecular Weight | 322.32 |
| PubChem CID | 135882612 |
| InChIKey | ZXECVVVXPHBGGX-DJLDLDEBSA-N |
| Purity | >=98.0% (HPLC) |
Condiciones de almacenamiento
+2 to +8 C
Atributos técnicos
- Nucleobase
- Guanine
- Sugar
- 2'-Deoxyribose
- Base protection
- N2-Dimethylaminomethylene (dmf)
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 1 g; 5 g; 10 g; 20 g; 25 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 500 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- 10 mM x 1 mL in DMSO supplied solution; 10 mM x 1 mL in DMSO solid-plus-solvent kit
- Water content
- <=2% KF
- Physical form
- white to off-white powder
- Stability
- User-prepared stock solution: 6 months at -80 C; 1 month at -20 C
Contexto de aplicación
- Base-protected DNA building block: the N2-dimethylformamidine group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanine (dG) monomer precursor context: CH64078 is the dmf-protected 2'-deoxyguanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64078 provides the N2-dmf-2'-deoxyguanosine identity for nucleoside chemistry research.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 135882612
PubChem · CID 135882612
Preguntas frecuentes
How does it differ from N2-isobutyryl-2'-deoxyguanosine?
Both protect the guanine N2-amine, but this one uses a dimethylformamidine (dmf) group rather than isobutyryl. N2-isobutyryl-2'-deoxyguanosine is cataloged separately.
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