N4-Benzoyl-2'-fluoro-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C16H16FN3O5
- PM
- 349.31
- Pureza
- >=98.0% (HPLC)
N4-Benzoyl-2'-fluoro-2'-deoxycytidine is 2'-fluoro-2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64092 is identified by CAS 146954-76-9, molecular formula C16H16FN3O5, molecular weight 349.31, PubChem CID 54266478, and InChIKey RHCOKFXBQWNMHE-BPGGGUHBSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Sinónimos
N4-Benzoyl-2'-fluoro-2'-deoxycytidine; N4-Bz-2'-F-dC; 2'-F-rC(Bz)
Identidad y especificaciones
| Catalog No. | CH64092 |
| CAS No. | 146954-76-9 |
| Molecular Formula | C16H16FN3O5 |
| Molecular Weight | 349.31 |
| PubChem CID | 54266478 |
| InChIKey | RHCOKFXBQWNMHE-BPGGGUHBSA-N |
| Purity | >=98.0% (HPLC) |
Condiciones de almacenamiento
2-8 C; keep dark and dry
Atributos técnicos
- Nucleobase
- Cytosine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white powder
Contexto de aplicación
- Base-protected 2'-F building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- Nucleoside chemistry identity: a defined N4-benzoyl-2'-fluoro-2'-deoxycytidine compound for nucleoside chemistry research.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 54266478
PubChem · CID 54266478
Preguntas frecuentes
How does it differ from N4-benzoyl-2'-O-methylcytidine?
Both are N4-benzoyl base-protected cytidines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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