5'-O-DMT-N6-benzoyl-2'-O-methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C39H37N5O7
- PM
- 687.7
- Pureza
- >=99%
5'-O-DMT-N6-benzoyl-2'-O-methyladenosine is 2'-O-methyladenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64116 is identified by CAS 110764-72-2, molecular formula C39H37N5O7, molecular weight 687.7, PubChem CID 10770884, and InChIKey SARHDAQOZNKZCC-CJEGOSRCSA-N.
It is a 2'-OMe-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Sinónimos
5'-O-DMT-N6-benzoyl-2'-O-methyladenosine; 5'-O-DMT-2'-OMe-rA(Bz); DMT-2'-OMe-rA(Bz)
Identidad y especificaciones
| Catalog No. | CH64116 |
| CAS No. | 110764-72-2 |
| Molecular Formula | C39H37N5O7 |
| Molecular Weight | 687.7 |
| PubChem CID | 10770884 |
| InChIKey | SARHDAQOZNKZCC-CJEGOSRCSA-N |
| Purity | >=99% |
Condiciones de almacenamiento
2-8 C
Atributos técnicos
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-Methyl
- Base protection
- N6-Benzoyl
- Grade
- N (Normal)
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white to off-white powder
Contexto de aplicación
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-OMe modification context: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
- N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 10770884
PubChem · CID 10770884
Preguntas frecuentes
How does it differ from N6-benzoyl-2'-O-methyladenosine?
Both carry an N6-benzoyl-protected 2'-O-methyladenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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