5'-O-DMT-N4-benzoyl-2'-O-methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C38H37N3O8
- PM
- 663.7
- Pureza
- 99.52%
5'-O-DMT-N4-benzoyl-2'-O-methylcytidine is 2'-O-methylcytidine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N4-benzoyl base-protecting group. CH64117 is identified by CAS 110764-74-4, molecular formula C38H37N3O8, molecular weight 663.7, PubChem CID 13872214, and InChIKey WXJKGOQQYUVNQW-YDXJMRNDSA-N.
It is a 2'-OMe-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N4-benzoyl group masks the cytosine exocyclic amine and is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Sinónimos
5'-O-DMT-N4-benzoyl-2'-O-methylcytidine; 5'-O-DMT-2'-OMe-rC(Bz); DMT-2'-OMe-rC(Bz)
Identidad y especificaciones
| Catalog No. | CH64117 |
| CAS No. | 110764-74-4 |
| Molecular Formula | C38H37N3O8 |
| Molecular Weight | 663.7 |
| PubChem CID | 13872214 |
| InChIKey | WXJKGOQQYUVNQW-YDXJMRNDSA-N |
| Purity | 99.52% |
Condiciones de almacenamiento
2-8 C
Atributos técnicos
- Nucleobase
- Cytosine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-Methyl
- Base protection
- N4-Benzoyl
- Packaging
- 5 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 250 g; 500 g; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white to off-white powder
- Stability
- 3 years at -20 C
Contexto de aplicación
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-OMe modification context: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
- N4-benzoyl base protection: the benzoyl group masks the cytosine exocyclic amine during synthesis and is removed at final deprotection.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 13872214
PubChem · CID 13872214
Preguntas frecuentes
How does it differ from N4-benzoyl-2'-O-methylcytidine?
Both carry an N4-benzoyl-protected 2'-O-methylcytidine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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