2'-OMe-Adenosine (Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- FM
- C48H54N7O8P
- PM
- 888.0
- Pureza
- 100.0% (NMR)
2'-OMe-Adenosine (Bz) CE Phosphoramidite is the 2'-O-methyl adenosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2'-O-methyladenosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65017 is identified by CAS 110782-31-5, molecular formula C48H54N7O8P, molecular weight 888.0, PubChem CID 13872235, and InChIKey AZCGOTUYEPXHMJ-PSVHYZMASA-N.
Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Sinónimos
DMT-2'-OMe-rA(Bz) phosphoramidite; 5'-O-DMT-N6-benzoyl-2'-O-methyladenosine 3'-CE phosphoramidite
Identidad y especificaciones
| Catalog No. | CH65017 |
| CAS No. | 110782-31-5 |
| Molecular Formula | C48H54N7O8P |
| Molecular Weight | 888.0 |
| PubChem CID | 13872235 |
| InChIKey | AZCGOTUYEPXHMJ-PSVHYZMASA-N |
| Purity | 100.0% (NMR) |
Condiciones de almacenamiento
-20 C
Atributos técnicos
- Monomer class
- 2'-O-methyl RNA CE phosphoramidite
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N6-Benzoyl
- Grade
- Standard; TheraPure
- Packaging
- 250 mg; 1 g; 5 g; 10 g; 500 g; Custom packaging on request
- Water content
- <=0.2% by Karl Fischer
- Physical form
- white powder
Contexto de aplicación
- 2'-OMe RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- 2'-OMe sugar modification: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
- 5'-DMT + N6-benzoyl protection: the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 13872235
PubChem · CID 13872235
Preguntas frecuentes
How does it relate to 5'-O-DMT-N6-benzoyl-2'-O-methyladenosine?
It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.
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