L96 Block 1 (DMT-Protected Pyrrolidine Linker Acid)
Oligonucleotide Conjugation & Delivery Ligands
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Conjugation & Delivery Ligands
- FM
- C38H49NO7
- PM
- 631.8
- Pureza
- >=97%
CH67012 is a DMT-protected chiral pyrrolidine linker acid, also known as L96 Block 1 and (3R,5S)-5-O-DMT-3-pyrrolidinol-12-oxododecanoic acid. Its identifiers are CAS 1159408-70-4, molecular formula C38H49NO7, molecular weight 631.8, and PubChem CID 57874622.
The structure contains a terminal carboxylic acid, a free secondary alcohol on the pyrrolidine ring, and a hydroxymethyl group protected as a dimethoxytrityl (DMT) ether. These differentiated functional groups make it an upstream linker/scaffold intermediate for staged L96 conjugation chemistry.
Some supplier catalogs call this material "Peracetylated GalNAc-L96-Acid-2." That name is retained as a catalog alias only: the CAS-resolved structure does not contain a GalNAc sugar or acetate ester groups.
Sinónimos
L96 Block 1; G1-20; Peracetylated GalNAc-L96-Acid-2 (supplier alias only)
Identidad y especificaciones
| Catalog No. | CH67012 |
| CAS No. | 1159408-70-4 |
| Molecular Formula | C38H49NO7 |
| Molecular Weight | 631.8 |
| PubChem CID | 57874622 |
| InChIKey | CEYLTMDXADTBEL-JHOUSYSJSA-N |
| Canonical Name | 12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxypyrrolidin-1-yl]-12-oxododecanoic acid |
| Purity | >=97% |
Condiciones de almacenamiento
-20 +/- 5 C
Atributos técnicos
- Building-block class
- DMT-protected chiral pyrrolidine linker acid
- Protected functionality
- Hydroxymethyl group as DMT ether
- Exposed handles
- Terminal carboxylic acid and secondary alcohol
- Assembly role
- Upstream L96 scaffold intermediate
- Packaging
- 10 mg; 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; 7 kg; 10 kg; 15 kg; 25 kg; Custom packaging on request
- Physical form
- white to light yellow powder
- Stability
- powder 3 years; in solvent at -80 C for 1 year
Contexto de aplicación
- L96 linker/scaffold assembly: an upstream protected pyrrolidine block used in L96-related conjugation chemistry.
- Carboxylic-acid coupling: the terminal carboxylic acid provides a defined handle for amide-forming or related coupling steps.
- Staged hydroxyl functionalization: the pyrrolidine secondary alcohol remains available while the hydroxymethyl group is protected as a DMT ether.
Recursos técnicos relacionados
administración dirigida a hepatocitos
ligandos GalNAc, grupos reactivos de conjugación de oligos, conjugados lipídicos y enlazadores para administración dirigida al hígado.
GalNAc vs conjugación lipídica
Comparar GalNAc multivalente dirigido a receptor y conjugación lipídica dependiente de estructura como estrategias distintas.
Fuentes públicas
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- Compuesto de PubChem 57874622
PubChem · CID 57874622
Preguntas frecuentes
What is CH67012 used for?
It is a DMT-protected chiral pyrrolidine linker acid used as an upstream L96 scaffold intermediate. The terminal carboxylic acid and free secondary alcohol provide differentiated reaction handles while the hydroxymethyl group remains DMT-protected.
Does CAS 1159408-70-4 contain a GalNAc sugar or acetate protecting groups?
No. PubChem CID 57874622 resolves this CAS to C38H49NO7, a DMT-protected pyrrolidine linker acid with no GalNAc sugar and no acetate ester. 'Peracetylated GalNAc-L96-Acid-2' is a supplier catalog alias, not a literal structural description.
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