2'-O-Propargyl-uridine
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione
Resumen del producto
Vista rápida
- Familia de productos
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Nombre químico
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione
- FM
- C12H14N2O6
- PM
- 282.25
- Pureza
- 99% (HPLC)
2'-O-Propargyl-uridine is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 129778-58-1, molecular formula C12H14N2O6, molecular weight 282.25, and PubChem CID 15747441.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts, including propargyl uridine-based RNA analogue chemistry. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Sinónimos
2'-O-propargyluridine; 2'-O-propargyl uridine
Identidad y especificaciones
| Catalog No. | CH70070 |
| CAS No. | 129778-58-1 |
| Molecular Formula | C12H14N2O6 |
| Molecular Weight | 282.25 |
| Exact Mass | 282.08518617 |
| PubChem CID | 15747441 |
| InChIKey | SJIYVXTZWZSVLZ-QCNRFFRDSA-N |
| Structural Note | Uridine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | 99% (HPLC) |
Condiciones de almacenamiento
<-15 C; keep container tightly closed
Atributos técnicos
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- Uracil
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 10 kg; 25 kg; 50 kg; Custom packaging on request
- Physical form
- White powder
Contexto de aplicación
- Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation, DNA click-modification, and propargyl uridine-based RNA analogue contexts.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
- Modified-uridine reference: use as a structure and identifier reference for 2'-O-propargyl uridine chemistry.
Recursos técnicos relacionados
Fuentes públicas
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- Compuesto de PubChem 15747441
PubChem · CID 15747441
Preguntas frecuentes
What is 2'-O-Propargyl-uridine?
It is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 129778-58-1 as CID 15747441.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide and RNA analogue chemistry contexts.
Is CH70070 a phosphoramidite monomer?
No. CH70070 is documented as the modified nucleoside 2'-O-Propargyl-uridine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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