DOTAP
化学名
2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride
DOTAP•LNP
Structure: 
製品番号
CH51014
CAS
132172-61-3
分子式
C42H80ClNO4
分子量
698.56
仕様
| Catalog No. | CH51014 |
| CAS No. | 132172-61-3 |
| Molecular Formula | C42H80ClNO4 |
| Molecular Weight | 698.56 |
CHEMOS Support for This Category
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
概要
DOTAP (also known as 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride) (CAS 132172-61-3, MF C42H80ClNO4, MW 698.56) is an ionizable lipid analog studied in lipid nanoparticle (LNP) formulations for nucleic acid delivery research, including mRNA and siRNA platforms. Practical chemistry topics around this compound include head-group structure, ester or amine linker chemistry, and tail unsaturation. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.
アプリケーション
- DOTAP (132172-61-3) supply and analog preparation for research programs
- Analytical method development for ionizable lipid related substances
- Ionizable lipid library and head-group / tail analog screening
- Custom analog synthesis with controlled head-group and tail variants