CHEMOS
DOTAP

DOTAP

Chemical Name

2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride

DOTAP•LNP
Structure: DOTAP structure, CAS 132172-61-3, MW 698.56
Product No
CH51014
CAS
132172-61-3
MF
C42H80ClNO4
MW
698.56
Specification
Catalog No.CH51014
CAS No.132172-61-3
Molecular FormulaC42H80ClNO4
Molecular Weight698.56

CHEMOS Support for This Category

CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.

Overview

DOTAP (also known as 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride) (CAS 132172-61-3, MF C42H80ClNO4, MW 698.56) is an ionizable lipid analog studied in lipid nanoparticle (LNP) formulations for nucleic acid delivery research, including mRNA and siRNA platforms. Practical chemistry topics around this compound include head-group structure, ester or amine linker chemistry, and tail unsaturation. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • DOTAP (132172-61-3) supply and analog preparation for research programs
  • Analytical method development for ionizable lipid related substances
  • Ionizable lipid library and head-group / tail analog screening
  • Custom analog synthesis with controlled head-group and tail variants

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