CHEMOS
DOTMA

DOTMA

Chemical Name

2,3-bis[(E)-octadec-9-enoxy]propyl-trimethylazanium chloride

DOTMA•LNP
Structure: DOTMA structure, CAS 104872-42-6, MW 670.59
Product No
CH51032
CAS
104872-42-6
MF
C42H84ClNO2
MW
670.59
Specification
Catalog No.CH51032
CAS No.104872-42-6
Molecular FormulaC42H84ClNO2
Molecular Weight670.59

CHEMOS Support for This Category

CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.

Overview

DOTMA (also known as 2,3-bis[(E)-octadec-9-enoxy]propyl-trimethylazanium chloride) (CAS 104872-42-6, MF C42H84ClNO2, MW 670.59) belongs to the ionizable lipid class used in LNP delivery system research for mRNA, siRNA and gene-editing cargos. Programs working with this compound usually examine the head-group / tail combination, related-substance profile, and stereochemistry. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • DOTMA (CAS 104872-42-6) preparation, route refinement, and analytical-control planning
  • Ionizable lipid library and head-group / tail analog screening
  • Custom analog synthesis with controlled head-group and tail variants
  • Analytical method development for ionizable lipid related substances

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