CHEMOS
Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid

Chemical Name

2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid•ADC linker
Structure: Fmoc-8-amino-3,6-dioxaoctanoic acid structure, CAS 166108-71-0, MW 385.41
Product No
CH53001
CAS
166108-71-0
MF
C21H23NO6
MW
385.41
Specification
Catalog No.CH53001
CAS No.166108-71-0
Molecular FormulaC21H23NO6
Molecular Weight385.41

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

Fmoc-8-amino-3,6-dioxaoctanoic acid (also known as 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid) (CAS 166108-71-0, MF C21H23NO6, MW 385.41) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • Fmoc-8-amino-3,6-dioxaoctanoic acid (CAS 166108-71-0) preparation, route refinement, and analytical-control planning
  • Click-chemistry coupling (DBCO / azide) for bioconjugation programs
  • Process-development support for scalable linker preparation
  • Bioconjugation handle for site-specific cysteine / lysine attachment

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