H-Glu-OtBu
Chemical Name
(4S)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
H-Glu-OtBu•ADC linker
Structure: 
Product No
CH53009
CAS
45120-30-7
MF
C9H17NO4
MW
203.24
Specification
| Catalog No. | CH53009 |
| CAS No. | 45120-30-7 |
| Molecular Formula | C9H17NO4 |
| Molecular Weight | 203.24 |
CHEMOS Support for This Category
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
Overview
H-Glu-OtBu (also known as (4S)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid) (CAS 45120-30-7, MF C9H17NO4, MW 203.24) is used as a linker / reactive-handle building block in ADC and bioconjugation research. Programs working with this compound usually examine selectivity of the bioconjugation chemistry, linker stability, and downstream payload release. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.
Applications
- H-Glu-OtBu (45120-30-7) as a starting point for downstream chemistry programs
- Cleavable peptide-linker design and intracellular-release studies
- Custom linker / payload-linker synthesis on request
- Antibody-drug conjugate (ADC) linker chemistry research
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