CHEMOS
(S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Chemical Name

(3S)-3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

(S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione•Molecular Glues
Structure: (S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione structure, CAS 202271-91-8, MW 259.26
Product No
CH57010
CAS
202271-91-8
MF
C13H13N3O3
MW
259.26
Specification
Catalog No.CH57010
CAS No.202271-91-8
Molecular FormulaC13H13N3O3
Molecular Weight259.26

CHEMOS Support for This Category

CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.

Overview

(S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione (also known as (3S)-3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione) (CAS 202271-91-8, MF C13H13N3O3, MW 259.26) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • (S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione (CAS 202271-91-8) preparation, route refinement, and analytical-control planning
  • Analog screening for E3-ligase recruitment chemistry
  • Custom synthesis of analog series for SAR exploration
  • Process-development support for scalable scaffold preparation

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