2'-Deoxyuridine
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- MF
- C9H12N2O5
- MW
- 228.20
- Purity
- >99.0% (HPLC)
2'-Deoxyuridine (dU) is the uracil DNA nucleoside formed from uracil and 2-deoxy-β-D-ribose. CH64005 is listed under CAS 951-78-0, molecular formula C9H12N2O5, molecular weight 228.20, and PubChem CID 13712.
This record is distinct from uridine, the corresponding RNA nucleoside. In research literature, 2'-deoxyuridine appears as a substrate in thymidylate synthase activity assays and as a reference nucleoside for uracil-in-DNA and base-excision-repair studies.
Synonyms
2'-Deoxyuridine; deoxyuridine; dUrd; dU; 2'-deoxyribouridine
Identity and specifications
| Catalog No. | CH64005 |
| CAS No. | 951-78-0 |
| Molecular Formula | C9H12N2O5 |
| Molecular Weight | 228.20 |
| PubChem CID | 13712 |
| InChIKey | MXHRCPNRJAMMIM-SHYZEUOFSA-N |
| Purity | >99.0% (HPLC) |
Storage conditions
Room temperature; cool and dark place below 15 C; inert gas
Technical attributes
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- Nucleoside class
- Pyrimidine 2'-deoxyribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
Application context
- Thymidylate synthase assay research: [5-³H]-2'-deoxyuridine is reported as the substrate in in situ thymidylate synthase activity assays.
- Base-excision-repair studies: uracil arising from dU in DNA is removed by uracil-DNA glycosylase, placing deoxyuridine in uracil-in-DNA research contexts.
- dU nucleoside reference: CH64005 provides the dU identity for nucleoside and oligonucleotide chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 13712
PubChem · CID 13712
Frequently Asked Questions
Is CH64005 the DNA or RNA nucleoside?
It is 2'-deoxyuridine (dU), the deoxyribonucleoside of uracil. The RNA counterpart, uridine, is listed separately by CHEMOS.
Why is 2'-deoxyuridine used in DNA-repair research?
Uracil that ends up in DNA (via dU/dUMP) is recognized and removed by uracil-DNA glycosylase, so 2'-deoxyuridine is a reference nucleoside in base-excision-repair studies.
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.