2',3'-Dideoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H13N3O3
- MW
- 211.22
- Purity
- >=98.0% (HPLC)
2',3'-Dideoxycytidine (ddC) is a pyrimidine 2',3'-dideoxynucleoside with cytosine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64016 is identified by CAS 7481-89-2, molecular formula C9H13N3O3, molecular weight 211.22, and PubChem CID 24066.
After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.
Synonyms
2',3'-Dideoxycytidine; ddC; zalcitabine (research reagent naming)
Identity and specifications
| Catalog No. | CH64016 |
| CAS No. | 7481-89-2 |
| Molecular Formula | C9H13N3O3 |
| Molecular Weight | 211.22 |
| PubChem CID | 24066 |
| InChIKey | WREGKURFCTUGRC-POYBYMJQSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Pyrimidine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg glass bottle with plastic insert; Custom packaging on request
- Physical form
- White to pale cream crystals or crystalline powder or powder
Application context
- Chain-terminator precursor: the corresponding ddCTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
- DNA-polymerase research: ddC provides the cytidine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
- Dideoxynucleoside reference: CH64016 provides the 2',3'-dideoxycytidine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 24066
PubChem · CID 24066
Frequently Asked Questions
Why is 2',3'-dideoxycytidine a chain terminator?
It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.
How is ddC different from 2'-deoxycytidine?
2'-Deoxycytidine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxycytidine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxycytidine is cataloged separately.
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