2',3'-Dideoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H13N5O3
- MW
- 251.24
- Purity
- >95.0% (HPLC, titration)
2',3'-Dideoxyguanosine (ddG) is a purine 2',3'-dideoxynucleoside with guanine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64017 is identified by CAS 85326-06-3, molecular formula C10H13N5O3, molecular weight 251.24, and PubChem CID 135463029.
After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.
Synonyms
2',3'-Dideoxyguanosine; ddG
Identity and specifications
| Catalog No. | CH64017 |
| CAS No. | 85326-06-3 |
| Molecular Formula | C10H13N5O3 |
| Molecular Weight | 251.24 |
| PubChem CID | 135463029 |
| InChIKey | OCLZPNCLRLDXJC-NTSWFWBYSA-N |
| Purity | >95.0% (HPLC, titration) |
Storage conditions
0-10 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Purine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg glass bottle with plastic insert; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- Solid; white to light yellow powder to crystal
Application context
- Chain-terminator precursor: the corresponding ddGTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
- DNA-polymerase research: ddG provides the guanosine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
- Dideoxynucleoside reference: CH64017 provides the 2',3'-dideoxyguanosine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135463029
PubChem · CID 135463029
Frequently Asked Questions
Why is 2',3'-dideoxyguanosine a chain terminator?
It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.
How is ddG different from 2'-deoxyguanosine?
2'-Deoxyguanosine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyguanosine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyguanosine is cataloged separately.
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