2',3'-Dideoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H12N2O4
- MW
- 212.20
- Purity
- >=98%
2',3'-Dideoxyuridine (ddU) is a pyrimidine 2',3'-dideoxynucleoside with uracil attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64019 is identified by CAS 5983-09-5, molecular formula C9H12N2O4, molecular weight 212.20, and PubChem CID 65161.
Its corresponding triphosphate, ddUTP, has been reported to be incorporated into a growing DNA chain at dTTP sites and to inhibit further elongation in an in vitro chain-termination study. This supports a narrow nucleic-acid research context for the dideoxynucleoside.
Synonyms
2',3'-Dideoxyuridine; ddU
Identity and specifications
| Catalog No. | CH64019 |
| CAS No. | 5983-09-5 |
| Molecular Formula | C9H12N2O4 |
| Molecular Weight | 212.20 |
| PubChem CID | 65161 |
| InChIKey | BTOTXLJHDSNXMW-POYBYMJQSA-N |
| Purity | >=98% |
Storage conditions
0-10 C
Technical attributes
- Nucleobase
- Uracil
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Pyrimidine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg; Custom packaging on request
- Physical form
- Solid; white to light yellow powder to crystal
- Stability
- >=4 years
Application context
- Chain-termination precursor: the corresponding ddUTP is reported to be incorporated into a growing DNA chain and inhibit further elongation in an in vitro study.
- Nucleic-acid research: ddU provides the uridine dideoxynucleoside identity for in vitro chain-termination comparisons.
- Dideoxynucleoside reference: CH64019 provides the 2',3'-dideoxyuridine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 65161
PubChem · CID 65161
Frequently Asked Questions
What chain-termination evidence supports 2',3'-dideoxyuridine?
In an in vitro study, the corresponding ddUTP was incorporated into a growing DNA chain at dTTP sites and inhibited further elongation. This page keeps that evidence in a research-only context.
How is ddU different from 2'-deoxyuridine?
2'-Deoxyuridine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyuridine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyuridine is cataloged separately.
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