2'-O-Methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H15N5O4
- MW
- 281.27
- Purity
- >98.0% (HPLC, titration)
2'-O-Methyladenosine (2'-OMe-A, Am) is adenosine with a 2'-O-methyl group on the ribose. CH64020 is identified by CAS 2140-79-6, molecular formula C11H15N5O4, molecular weight 281.27, and PubChem CID 102213.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while natural 2'-O-methylation is treated as an RNA-modification reference.
Synonyms
2'-O-Methyladenosine; 2'-OMe-A; Am
Identity and specifications
| Catalog No. | CH64020 |
| CAS No. | 2140-79-6 |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.27 |
| PubChem CID | 102213 |
| InChIKey | FPUGCISOLXNPPC-IOSLPCCCSA-N |
| Purity | >98.0% (HPLC, titration) |
Storage conditions
Frozen below 0 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified purine ribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Application context
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: 2'-O-methylation occurs naturally in RNA, making CH64020 relevant to tRNA/rRNA modification research.
- 2'-OMe ribonucleoside reference: CH64020 provides the 2'-O-methyladenosine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102213
PubChem · CID 102213
Frequently Asked Questions
What does the 2'-O-methyl group do?
A 2'-O-methyl group on the ribose is associated with higher nuclease resistance while retaining RNA-binding affinity, so it is commonly studied in antisense and siRNA oligonucleotide research.
Is 2'-O-methyladenosine a natural RNA modification?
Yes. 2'-O-methylation (for example Am / Gm34) occurs naturally in tRNA and rRNA, so 2'-O-methyladenosine is also a reference in RNA-modification research.
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