2'-O-Methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H15N3O5
- MW
- 257.24
- Purity
- >98.0% (HPLC, titration)
2'-O-Methylcytidine (2'-OMe-C, Cm) is cytidine with a 2'-O-methyl group on the ribose. CH64021 is identified by CAS 2140-72-9, molecular formula C10H15N3O5, molecular weight 257.24, and PubChem CID 150971.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while natural 2'-O-methylation is treated as an RNA-modification reference.
Synonyms
2'-O-Methylcytidine; 2'-OMe-C; Cm
Identity and specifications
| Catalog No. | CH64021 |
| CAS No. | 2140-72-9 |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.24 |
| PubChem CID | 150971 |
| InChIKey | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| Purity | >98.0% (HPLC, titration) |
Storage conditions
0-10 C
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 1 g listed size; 200 mg glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Application context
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: 2'-O-methylation occurs naturally in RNA, making CH64021 relevant to tRNA/rRNA modification research.
- 2'-OMe ribonucleoside reference: CH64021 provides the 2'-O-methylcytidine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 150971
PubChem · CID 150971
Frequently Asked Questions
What does the 2'-O-methyl group do?
A 2'-O-methyl group on the ribose is associated with higher nuclease resistance while retaining RNA-binding affinity, so it is commonly studied in antisense and siRNA oligonucleotide research.
Is 2'-O-methylcytidine a natural RNA modification?
Yes. 2'-O-methylation (Cm) occurs naturally in tRNA and rRNA, so 2'-O-methylcytidine is also a reference in RNA-modification research.
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