2'-O-Methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H14N2O6
- MW
- 258.23
- Purity
- >98.0% (HPLC, titration)
2'-O-Methyluridine (2'-OMe-U, Um) is uridine with a 2'-O-methyl group on the ribose. CH64023 is identified by CAS 2140-76-3, molecular formula C10H14N2O6, molecular weight 258.23, and PubChem CID 102212. It has the same molecular formula as 5-methyluridine but a different methyl position and structure.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while Um is treated as a natural RNA-modification reference.
Synonyms
2'-O-Methyluridine; 2'-OMe-U; Um
Identity and specifications
| Catalog No. | CH64023 |
| CAS No. | 2140-76-3 |
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| PubChem CID | 102212 |
| InChIKey | SXUXMRMBWZCMEN-ZOQUXTDFSA-N |
| Purity | >98.0% (HPLC, titration) |
Storage conditions
0-10 C
Technical attributes
- Nucleobase
- Uracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; 5 g listed size; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Application context
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: Um is a naturally occurring 2'-O-methyl RNA modification, making CH64023 relevant to RNA-modification research.
- 2'-OMe ribonucleoside reference: CH64023 provides the 2'-O-methyluridine identity for nucleoside chemistry comparisons.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102212
PubChem · CID 102212
Frequently Asked Questions
How is 2'-O-methyluridine different from 5-methyluridine?
Both share the formula C10H14N2O6, but 2'-O-methyluridine (Um) carries the methyl on the 2'-oxygen of the ribose, while 5-methyluridine (ribothymidine) carries it on carbon 5 of the base. They are constitutional isomers and are listed separately.
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