2'-O-Methyl-5-Methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H16N2O6
- MW
- 272.25
- Purity
- 100%
2'-O-Methyl-5-methyluridine (2'-OMe-5-Me-U; 2'-O-methylribothymidine, Tm) carries two modifications: a 2'-O-methyl group on the ribose and a 5-methyl group on the uracil base. CH64024 is identified by CAS 55486-09-4, molecular formula C11H16N2O6, molecular weight 272.25, and PubChem CID 191372.
In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, and 2'-O-methylation is a natural RNA-modification motif. CH64024 provides the defined dual 2'-O-methyl / 5-methyl uridine structure for oligonucleotide and modified-nucleoside comparisons; this does not establish the dual-modified structure itself as a natural RNA residue.
Synonyms
2'-O-Methyl-5-methyluridine; 2'-OMe-5-Me-U; 2'-O-methylribothymidine; Tm
Identity and specifications
| Catalog No. | CH64024 |
| CAS No. | 55486-09-4 |
| Molecular Formula | C11H16N2O6 |
| Molecular Weight | 272.25 |
| PubChem CID | 191372 |
| InChIKey | YHRRPHCORALGKQ-FDDDBJFASA-N |
| Purity | 100% |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- 5-Methyluracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 250 mg; 1 g; 5 g; 25 g; 100 g; Custom packaging on request
- Physical form
- Solid
- Stability
- >=4 years
Application context
- 2'-O-methyl oligonucleotide research: CH64024 is relevant to nuclease-resistant antisense and siRNA oligonucleotide studies involving 2'-O-methyl residues.
- Combined modified-nucleoside reference: it pairs a 2'-O-methyl sugar modification with a 5-methyl pyrimidine base for structural and nucleoside-chemistry comparisons.
- Modified ribonucleoside reference: CH64024 provides the 2'-O-methyl-5-methyluridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 191372
PubChem · CID 191372
Frequently Asked Questions
What two modifications does CH64024 carry?
It has a 2'-O-methyl group on the ribose and a 5-methyl group on the uracil base (i.e. 2'-O-methylribothymidine), combining a sugar and a base modification in one residue.
How is it different from 5-methyluridine and 2'-O-methyluridine?
5-Methyluridine has only the base 5-methyl; 2'-O-methyluridine has only the 2'-O-methyl; CH64024 has both. All three are cataloged separately.
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